Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Zhejiang University School of Medicine, Zhoushan, Zhejiang Province, China; Department of general surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang Province, China.
Cancer Chemotherapy Center, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang Province, China; Department of Hematology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang Province, China.
Thromb Res. 2024 Sep;241:109111. doi: 10.1016/j.thromres.2024.109111. Epub 2024 Aug 2.
Thrombosis is the primary cause of death in patients with cancer. Resveratrol inhibits platelet activation, a crucial pathophysiological basis of thrombosis, in healthy individuals. However, its effects and mechanisms of action in patients with colon cancer remain unknown. Here, we investigated the effect of resveratrol on platelet adhesion and aggregation in patients with colon cancer. Through numerous in vitro and in vivo analyses, including flow cytometry, western blotting, ELISA, and immunofluorescence and colon cancer rat models, we demonstrated that resveratrol reduced thrombosis in patients with colon cancer by inhibiting the phosphorylation of the MAPK and activating the cyclic-GMP/vasodilator-stimulated phosphoprotein pathway. These findings demonstrate the potential of resveratrol in reducing thrombosis in patients with colon cancer and could be used to develop novel therapeutic strategies for this condition.
血栓形成是癌症患者死亡的主要原因。白藜芦醇在健康个体中抑制血小板激活，这是血栓形成的关键病理生理基础。然而，其在结肠癌患者中的作用和作用机制尚不清楚。在这里，我们研究了白藜芦醇对结肠癌患者血小板黏附和聚集的影响。通过大量的体外和体内分析，包括流式细胞术、western blot、ELISA 和免疫荧光以及结肠癌大鼠模型，我们证明白藜芦醇通过抑制 MAPK 的磷酸化和激活环鸟苷酸/血管扩张刺激磷蛋白途径来减少结肠癌患者的血栓形成。这些发现表明白藜芦醇在减少结肠癌患者血栓形成方面具有潜力，并可用于开发该疾病的新治疗策略。
