探索五味子丙素通过PI3K/AKT/mTOR自噬途径治疗动脉粥样硬化的分子机制。

Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.

作者信息

Duan Hong, Li Han, Liu Tianyi, Chen Yuan, Luo Mengmeng, Shi Ying, Zhou Jing, Rashed Marwan M A, Zhai Kefeng, Li Lili, Wei Zhaojun

机构信息

School of Biological and Food Engineering, Engineering Research Center for Development and High Value Utilization of Genuine Medicinal Materials in North Anhui Province, Suzhou University, Suzhou, Anhui 234000, China.

College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China.

出版信息

ACS Omega. 2024 Jul 16;9(30):32920-32930. doi: 10.1021/acsomega.4c03738. eCollection 2024 Jul 30.

Atherosclerosis (AS) is a common cardiovascular disease that poses a major threat to health. is a medicinal and edible plant that is commonly used to treat cardiovascular diseases. In this paper, HPLC was used to detect and analyze 5 different components in . Network pharmacological predictions highlight the PI3K/AKT/mTOR pathway as an important pharmacological pathway. The effective ingredient Schisandrin C was screened by the molecular docking technique. ox-LDL-induced HUVECs were used to construct the atherosclerosis model for further experimental verification. The results showed that Schisandrin C interfered with the PI3K/AKT/mTOR autophagy pathway. This study lays a foundation for the further application of Schisandrin C in the prevention and treatment of atherosclerosis in the future.

动脉粥样硬化（AS）是一种常见的心血管疾病，对健康构成重大威胁。[此处原文缺失植物名称]是一种常用的药食两用植物，用于治疗心血管疾病。本文采用高效液相色谱法（HPLC）检测和分析了[此处原文缺失植物名称]中的5种不同成分。网络药理学预测突出了PI3K/AKT/mTOR途径作为一条重要的药理途径。通过分子对接技术筛选出有效成分五味子丙素。利用氧化型低密度脂蛋白（ox-LDL）诱导的人脐静脉内皮细胞（HUVECs）构建动脉粥样硬化模型进行进一步的实验验证。结果表明，五味子丙素干扰了PI3K/AKT/mTOR自噬途径。本研究为五味子丙素未来在动脉粥样硬化防治中的进一步应用奠定了基础。