Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
BMC Endocr Disord. 2024 Aug 5;24(1):140. doi: 10.1186/s12902-024-01675-5.
Promoting prevalence of metabolic syndrome (MetS) in Rheumatoid arthritis (RA) patients might occur secondary to RA therapy as well as sedentary life style. However, conflicting observations have been reported on the correlation between MetS and RA. This study aimed to determine the frequency of MetS and association of its components in RA.
In this study, 500 RA patients and 500 age- and gender-matched healthy controls were enrolled. MetS was fulfilled through the International Diabetes Federation (IDF) criteria. A multivariate regression model was used to control for variables independently associated with the risk of MetS in RA patients.
The prevalence of MetS was 58.8% on IDF criteria in RA patients that was higher than controls (20.4%). Higher incidence of cardiovascular disease (CVD), the familial history of CVD, hypertension, type 2 diabetes mellitus (T2DM), smoking, dyslipidemia, and higher levels of body mass index (BMI), waist circumference (WC), total cholesterol level, fasting blood sugar (FBS), triglyceride (TG) level, low-density lipoprotein (LDL) level, while lower levels of high-density lipoprotein (HDL) were associated with an increased risk of MetS in RA patients. Multivariate regression analysis indicated that age, WC, dyslipidemia, LDL, and DAS28 were independent predictors of MetS in the RA patients.
The prevalence of MetS is higher in RA patients. Our findings suggest an association between cardiovascular risk factors and the increased prevalence of MetS in RA patients.
代谢综合征（MetS）在类风湿关节炎（RA）患者中的流行可能继发于 RA 治疗以及久坐的生活方式。然而，关于 MetS 与 RA 之间的相关性，已有相互矛盾的观察结果报告。本研究旨在确定 RA 患者中 MetS 的频率及其各成分的相关性。
本研究纳入了 500 例 RA 患者和 500 例年龄和性别匹配的健康对照者。采用国际糖尿病联合会（IDF）标准来确定 MetS。采用多元回归模型来控制与 RA 患者 MetS 风险相关的独立变量。
根据 IDF 标准，RA 患者中 MetS 的患病率为 58.8%，高于对照组（20.4%）。心血管疾病（CVD）、CVD 家族史、高血压、2 型糖尿病（T2DM）、吸烟、血脂异常以及 BMI、腰围（WC）、总胆固醇水平、空腹血糖（FBS）、甘油三酯（TG）水平、低密度脂蛋白（LDL）水平较高，而高密度脂蛋白（HDL）水平较低，与 RA 患者 MetS 风险增加相关。多变量回归分析表明，年龄、WC、血脂异常、LDL 和 DAS28 是 RA 患者 MetS 的独立预测因子。
RA 患者中 MetS 的患病率较高。我们的研究结果表明，心血管危险因素与 RA 患者中 MetS 患病率增加之间存在关联。
