孤独和社会隔离与青光眼风险增加相关：一项英国生物银行队列研究。
Loneliness and social isolation are associated with an increased risk of glaucoma: a UK Biobank cohort study.
机构信息
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China.
出版信息
BMC Public Health. 2024 Aug 5;24(1):2109. doi: 10.1186/s12889-024-19649-6.
BACKGROUND
Loneliness and social isolation have been found to be associated with various health-related outcomes. Our study aimed to evaluate the association of loneliness and social isolation with the risk of glaucoma.
METHODS
A total of 373,330 participants from the UK Biobank without glaucoma at recruitment were included in this study. Self-reported questionnaires were used to define loneliness and social isolation. Incident glaucoma events were identified by hospital inpatient admissions and self-reported data. COX proportional hazards models adjusted for sociodemographic, lifestyle, and health-related factors were used to estimate hazard ratios (HRs) and 95% CIs.
RESULTS
During a median follow-up of 13.1 (interquartile range: 12.3-13.9) years, 6,489 participants developed glaucoma. After adjusting for confounding factors, loneliness (yes vs. no: adjusted HR: 1.16; 95% CI: 1.04-1.30; P = 0.009) and social isolation (yes vs. no: adjusted HR: 1.08; 95% CI: 1.01-1.16; P = 0.033) were associated with an increased risk of glaucoma.
CONCLUSIONS
In this population-based prospective cohort study, loneliness and social isolation were associated with a higher risk of glaucoma.
背景
孤独和社会隔离与各种与健康相关的结果有关。我们的研究旨在评估孤独和社会隔离与青光眼风险之间的关系。
方法
本研究共纳入 373330 名在招募时无青光眼的英国生物库参与者。使用自我报告问卷来定义孤独和社会隔离。通过医院住院和自我报告数据确定青光眼事件的发生。使用调整了社会人口统计学、生活方式和健康相关因素的 COX 比例风险模型来估计风险比（HR）和 95%置信区间（CI）。
结果
在中位数为 13.1 年（四分位间距：12.3-13.9）的随访期间，6489 名参与者发生了青光眼。在调整了混杂因素后，孤独（是与否：调整后的 HR：1.16；95%CI：1.04-1.30；P=0.009）和社会隔离（是与否：调整后的 HR：1.08；95%CI：1.01-1.16；P=0.033）与青光眼风险增加相关。
结论
在这项基于人群的前瞻性队列研究中，孤独和社会隔离与青光眼风险增加相关。
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