Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, P.O.Box: 1871, Mekelle, Tigray, Ethiopia.
Department of Pharmacy, Quiha General Hospital, Mekelle, Tigray, Ethiopia.
AIDS Res Ther. 2024 Aug 5;21(1):50. doi: 10.1186/s12981-024-00635-2.
This study aimed to assess the prevalence and reasons for nonadherence to cotrimoxazole prophylaxis therapy. A cross-sectional study was conducted among people living with HIV attending Ayder Comprehensive Specialized Hospital. Data were collected through interviews and reviews of medical records. Binary logistic regression was employed to analyze factors associated with CPT nonadherence. Approximately two-thirds (65.5%) of the participants were non-adherent to co-trimoxazole prophylaxis therapy. The main reasons for non-adherence were side effects, pill fatigue and forgetfulness. Strategies to improve adherence to co-trimoxazole prophylaxis therapy should focus on the combined patient, clinical and medication related issues of people living with HIV.
本研究旨在评估复方新诺明预防治疗不依从的流行率和原因。采用横断面研究方法，在亚的斯亚贝巴综合专科医院就诊的 HIV 感染者中开展。通过访谈和病历回顾收集数据。采用二元逻辑回归分析与 CPT 不依从相关的因素。约三分之二（65.5%）的参与者不依从复方新诺明预防治疗。不依从的主要原因是副作用、药物疲劳和健忘。提高 HIV 感染者对复方新诺明预防治疗依从性的策略应侧重于患者、临床和药物相关问题的综合。
