Hauryski Sarah, Potts Alexandra, Swigart Alison, Babinski Dara, Waschbusch Daniel A, Forrest Lauren N
Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA, USA.
Department of Psychiatry, Medical University of South Carolina, Charleston, USA.
Borderline Personal Disord Emot Dysregul. 2024 Aug 6;11(1):17. doi: 10.1186/s40479-024-00262-3.
Psychiatric medications are not efficacious for treating borderline personality disorder (BPD), yet many patients with BPD are prescribed multiple psychiatric medications. This study aimed to (1) characterize psychiatric medication prescribing practices in adolescents with BPD and (2) assess whether demographic features are associated with prescribing practices.
This sample was N = 2950 pediatric patients with BPD (ages 10-19) across the U.S. Data came from the NeuroBlu database, which includes data from 30 U.S. healthcare systems and hundreds of hospitals. Poisson regressions and chi-squared tests determined whether gender, race, and ethnicity were associated with (1) number of unique psychiatric medications prescribed and (2) number of unique medication classes prescribed.
Roughly two-thirds (64.85%) of youth were prescribed any medications. Of these youth, 79.40% were prescribed ≥ 2 unique medications and 72.66% were prescribed ≥ 2 unique medications classes. The mean number of unique medications was 3.50 (SD = 2.50). The mean number of unique medication classes was 2.35 (SD = 1.15). The most commonly prescribed medication classes were antidepressants and antipsychotics, which were often prescribed in combination. Poisson regressions showed that boys were prescribed more unique medications (M = 3.67) than girls (M = 3.47). Non-Latinx youth were prescribed significantly more unique medications (M = 44.12) than Latinx youth (M = 3.60, p = .01).
Results characterize psychiatric medication prescribing practices in youth with BPD. Prescribing practices vary by demographics, such that boys and non-Latinx youth are prescribed more medications than girls and Latinx youth, respectively. These demographic differences suggest that prescribers may treat BPD differently based on patient demographic characteristics.
精神科药物对治疗边缘型人格障碍（BPD）无效，但许多BPD患者却被开具了多种精神科药物。本研究旨在（1）描述青少年BPD患者的精神科药物处方情况，以及（2）评估人口统计学特征是否与处方情况相关。
该样本为美国2950名患有BPD的儿科患者（年龄在10至19岁之间）。数据来自NeuroBlu数据库，该数据库包含来自美国30个医疗系统和数百家医院的数据。泊松回归和卡方检验确定了性别、种族和民族是否与（1）开具的独特精神科药物数量以及（2）开具的独特药物类别数量相关。
大约三分之二（64.85%）的青少年被开具了任何药物。在这些青少年中，79.40%被开具了≥2种独特药物，72.66%被开具了≥2种独特药物类别。独特药物的平均数量为3.50（标准差=2.50）。独特药物类别的平均数量为2.35（标准差=1.15）。最常开具的药物类别是抗抑郁药和抗精神病药，且经常联合使用。泊松回归显示，男孩开具的独特药物（均值=3.67）比女孩（均值=3.47）更多。非拉丁裔青少年开具的独特药物（均值=44.12）明显多于拉丁裔青少年（均值=3.60，p=0.01）。
研究结果描述了青少年BPD患者的精神科药物处方情况。处方情况因人口统计学特征而异，即男孩和非拉丁裔青少年分别比女孩和拉丁裔青少年被开具更多药物。这些人口统计学差异表明，开药者可能会根据患者的人口统计学特征对BPD进行不同的治疗。
