抗合成酶综合征：关于肺孢子菌病风险升高的病例报告

Anti-Synthetase Syndrome: A Case Report on the Elevated Risk of Pneumocystosis.

作者信息

Es-Sabbahi Btissame, Serraj Mounia, Benjelloun Mohammed Chakib, ElBiaze Mohamed, Amara Bouchra

机构信息

Pulmonology Department, Hassan II University Hospital, University of Sidi Mohammed Ben Abdellah, Fez, MAR.

出版信息

Cureus. 2024 Jul 6;16(7):e63982. doi: 10.7759/cureus.63982. eCollection 2024 Jul.

DOI:10.7759/cureus.63982

PMID:39104973

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11299875/

Abstract

pneumonia (PCP), now referred to as pneumonia (PJP), occurs in immunocompromised patients. It is particularly associated with cellular immunodeficiency due to certain diseases or treatments. The risk of PCP is likely correlated with the severity of cellular immunity damage. However, excluding AIDS, the precise degree of immunosuppression required to develop PCP is not yet clearly understood. We report the case of a 58-year-old patient who presented with progressively worsening dyspnea. The clinical examination revealed a SaO₂ of 88% on room air and the appearance of mechanic's hands. A thoracic CT scan showed interstitial lung disease (ILD). The immunological work-up was positive for antinuclear antibodies (ANA) and anti-JO-1 antibodies. Bronchoscopy with bronchoalveolar lavage (BAL) was performed, and the test for PJP came back positive.

摘要

肺孢子菌肺炎（PCP），现称为肺孢子菌肺炎（PJP），发生于免疫功能低下的患者。它尤其与某些疾病或治疗导致的细胞免疫缺陷有关。PCP的风险可能与细胞免疫损伤的严重程度相关。然而，除艾滋病外，发生PCP所需的确切免疫抑制程度尚不清楚。我们报告一例58岁患者，其出现进行性加重的呼吸困难。临床检查显示在室内空气中氧饱和度为88%，并出现技工手。胸部CT扫描显示间质性肺疾病（ILD）。免疫检查抗核抗体（ANA）和抗JO - 1抗体呈阳性。进行了支气管镜检查及支气管肺泡灌洗（BAL），PJP检测呈阳性。