Zhang Wen-Wen, Chen Li, Wu Yu-Fang
Department of Infectious Diseases, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China.
World J Clin Cases. 2024 Aug 6;12(22):4956-4964. doi: 10.12998/wjcc.v12.i22.4956.
In patients with liver failure (LF), the high rate of secondary infections, which are associated with poor prognosis, highlights the clinical significance of understanding the underlying risk factors and implementing targeted intervention programs.
To investigate risk factors for secondary infections in patients with LF and evaluate the effectiveness of comprehensive nursing interventions.
This retrospective study included 64 patients with LF, including 32 with and 32 without secondary infections. A questionnaire was used to collect data on age; laboratory parameters, including total and direct bilirubin, prothrombin time, blood ammonia, and other biochemical parameters; invasive procedures; and complications. Patients with secondary infections received comprehensive nursing intervention in addition to routine nursing care, whereas those without secondary infections received only routine nursing care to compare the effect of nursing intervention on outcomes.
The infection rate, which was not associated with age or complications, was significantly associated with biochemical parameters and invasive procedures ( < 0.05). The infection rate was 61.6% in patients who had undergone invasive procedures and 32.1% in those who had not undergone invasive procedures during the hospital stay. The infection rate was also significantly associated with the type of LF ( < 0.05), with the lowest rate observed in patients with acute LF and the highest rate observed in those with subacute LF. The nursing satisfaction rate was 58.3% in the uninfected group and 91.7% in the infected group, indicating significantly higher satisfaction in the infected group ( < 0.05).
In patients with LF, the rate of secondary infections was high and associated with biochemical parameters and type of LF. Comprehensive nursing intervention can improve patient satisfaction.
在肝衰竭（LF）患者中，继发感染发生率高且与预后不良相关，这凸显了了解潜在危险因素并实施针对性干预方案的临床意义。
探讨LF患者继发感染的危险因素，并评估综合护理干预的效果。
这项回顾性研究纳入了64例LF患者，其中32例有继发感染，32例无继发感染。采用问卷调查收集年龄、实验室参数（包括总胆红素和直接胆红素、凝血酶原时间、血氨及其他生化参数）、侵入性操作及并发症等数据。继发感染患者除接受常规护理外还接受综合护理干预，而无继发感染患者仅接受常规护理，以比较护理干预对结局的影响。
感染率与年龄或并发症无关，与生化参数和侵入性操作显著相关（<0.05）。住院期间接受侵入性操作的患者感染率为61.6%，未接受侵入性操作的患者感染率为32.1%。感染率也与LF类型显著相关（<0.05），急性LF患者感染率最低，亚急性LF患者感染率最高。未感染组护理满意度为58.3%，感染组为91.7%，表明感染组满意度显著更高（<0.05）。
LF患者继发感染率高，且与生化参数和LF类型相关。综合护理干预可提高患者满意度。
