Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., CB 8056, St. Louis, MO 63110-1093, USA.
Research Department, Fundación Huésped, Av. Forest 345 (C1427CEA) Buenos Aires, Argentina.
Infect Dis Clin North Am. 2024 Sep;38(3):531-557. doi: 10.1016/j.idc.2024.06.007.
We review the intersection of human immunodeficiency virus (HIV) and cancer globally, including the complex interplay of oncogenic infections, chronic inflammation, and behavioral and other factors in increasing cancer risk among people with HIV (PWH). We discuss current cancer screening, prevention, and treatment recommendations for PWH. Specific interventions include vaccination, behavioral risk reduction, timely HIV diagnosis and treatment, screening for specific cancer sites, and multifaceted treatment considerations unique to PWH including supportive care and drug interactions. Finally, the potential of novel therapies and the need for inclusive cancer clinical trials are highlighted. Collaborative multidisciplinary efforts are critical for continued progress against cancer among PWH.
我们综述了全球范围内人类免疫缺陷病毒(HIV)与癌症的关系,包括致癌感染、慢性炎症以及行为和其他因素在 HIV 感染者(PWH)中增加癌症风险方面的复杂相互作用。我们讨论了 PWH 的癌症筛查、预防和治疗建议。具体干预措施包括疫苗接种、减少行为风险、及时进行 HIV 诊断和治疗、对特定癌症部位进行筛查以及针对 PWH 独特的多方面治疗考虑因素,包括支持性护理和药物相互作用。最后,强调了新型治疗方法的潜力以及需要开展包容性癌症临床试验。多学科协作对于 PWH 防治癌症的持续进展至关重要。