Laboratory of Biorheology and Medical Ultrasonics (LBUM), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Institute of Biomedical Engineering, Université de Montréal, Montreal, Quebec, Canada.
J Ultrasound Med. 2024 Nov;43(11):2095-2108. doi: 10.1002/jum.16538. Epub 2024 Aug 8.
To assess the reproducibility of six ultrasound (US)-determined shear wave (SW) viscoelastography parameters for assessment of mechanical properties of the liver in volunteers and patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH).
This prospective, cross-sectional, institutional review board-approved study included 10 volunteers and 20 patients with MASLD or MASH who underwent liver US elastography twice, at least 2 weeks apart. SW speed (SWS), Young's modulus (E), shear modulus (G), SW attenuation (SWA), SW dispersion (SWD), and viscosity were computed from radiofrequency data recorded on a research US scanner. Linear mixed models were used to consider the sonographer on duty as a confounder. The reproducibility of measurements was assessed by intraclass correlation coefficient (ICC), coefficient of variation (CV), reproducibility coefficient (RDC), and Bland-Altman analyses.
The sonographer performing the exam had no impact on viscoelastic parameters (P > .05). ICCs of SWS, E, G, SWA, SWD, and viscosity were, respectively, 0.89 (95% confidence intervals [CI]: 0.79-0.95), 0.81 (95% CI: 0.79-0.95), 0.90 (95% CI: 0.80-0.95), 0.96 (95% CI: 0.93-0.98), 0.78 (95% CI: 0.60-0.89), and 0.90 (95% CI: 0.80-0.95); CVs were 11.9, 23.3, 24.2, 10.1, 29.0, and 32.2%; RDCs were 33.0, 64.5, 66.9, 27.7, 80.3, and 89.2%, and Bland-Altman mean biases and 95% limits of agreement were -0.05 (-0.45, 0.35) m/s, -0.61 (-5.33, 4.10) kPa, -0.25 (-2.06, 1.56) kPa, -0.01 (-0.27, 0.26) Np/m/Hz, -0.09 (-7.09, 6.91) m/s/kHz, and -0.33 (-2.60, 1.94) Pa/s, between the two visits.
US-determined viscoelastography parameters can be measured with high reproducibility and consistency between two visits 2 weeks apart on the same ultrasound machine.
评估六个体声（US）测定的剪切波（SW）黏弹性参数在评估志愿者和经活检证实的代谢功能相关脂肪性肝病（MASLD）或代谢相关脂肪性肝炎（MASH）患者肝脏机械特性方面的重复性。
本前瞻性、横断面、机构审查委员会批准的研究纳入了 10 名志愿者和 20 名 MASLD 或 MASH 患者，他们在至少 2 周的间隔时间内两次接受肝脏 US 弹性成像检查。从研究型 US 扫描仪上记录的射频数据中计算 SW 速度（SWS）、杨氏模量（E）、剪切模量（G）、SW 衰减（SWA）、SW 弥散（SWD）和粘度。线性混合模型用于考虑当班超声医师的混杂因素。通过组内相关系数（ICC）、变异系数（CV）、重复性系数（RDC）和 Bland-Altman 分析评估测量的重复性。
进行检查的超声医师对黏弹性参数没有影响（P>.05）。SWS、E、G、SWA、SWD 和粘度的 ICC 分别为 0.89（95%置信区间 [CI]：0.79-0.95）、0.81（95% CI：0.79-0.95）、0.90（95% CI：0.80-0.95）、0.96（95% CI：0.93-0.98）、0.78（95% CI：0.60-0.89）和 0.90（95% CI：0.80-0.95）；CV 分别为 11.9%、23.3%、24.2%、10.1%、29.0%和 32.2%；RDC 分别为 33.0%、64.5%、66.9%、27.7%、80.3%和 89.2%，Bland-Altman 平均偏差和 95%一致性区间分别为-0.05（-0.45，0.35）m/s、-0.61（-5.33，4.10）kPa、-0.25（-2.06，1.56）kPa、-0.01（-0.27，0.26）Np/m/Hz、-0.09（-7.09，6.91）m/s/kHz 和-0.33（-2.60，1.94）Pa/s，两次检查之间。
在同一台超声机器上，两次间隔 2 周的检查可以高度重现和一致地测量 US 测定的黏弹性参数。
