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离子束处理聚氨酯植入物的异物反应。

Foreign Body Reaction to Ion-Beam-Treated Polyurethane Implant.

作者信息

Chudinov Vyacheslav S, Shardakov Igor N, Litvinov Valery V, Solodnikov Sergey Y, Chudinova Elena Y, Kondyurina Irina V, Kondyurin Alexey V

机构信息

Institute of Continuous Media Mechanics, Ural Branch, Russian Academy of Sciences, Perm 614013, Russia.

Therapeutic Faculty, Perm State Medical University, Perm 614990, Russia.

出版信息

Materials (Basel). 2024 Aug 2;17(15):3833. doi: 10.3390/ma17153833.

DOI:10.3390/ma17153833
PMID:39124497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11313228/
Abstract

All artificial materials used for implantation into an organism cause a foreign body reaction. This is an obstacle for a number of medical technologies. In this work, we investigated the effect of high-energy ion bombardment on polyurethane for medical purposes and the reaction of body tissues to its insertion into the mouse organism. An analysis of the cellular response and shell thickness near the implant showed a decrease in the foreign body reaction for implants treated with high-energy ions compared to untreated implants. The decrease in the reaction is associated with the activation of the polyurethane surface due to the formation on the surface layer of condensed aromatic clusters with unbonded valences on the carbon atoms at the edges of such clusters and the covalent attachment of the organism's own proteins to the activated surface of the implant. Thus, immune cells do not identify the implant surface coated with its own proteins as a foreign body. The deactivation of free valences at the edges of aromatic structures due to the storage of the treated implant before surgery reduces surface activity and partially restores the foreign body response. For the greatest effect in eliminating a foreign body reaction, it is recommended to perform the operation immediately after treating the implant with high-energy ions, with minimal contact of the treated surface with any materials.

摘要

所有用于植入生物体的人工材料都会引发异物反应。这对许多医疗技术来说都是一个障碍。在这项工作中，我们研究了高能离子轰击对医用聚氨酯的影响以及身体组织对其植入小鼠体内的反应。对植入物附近的细胞反应和外壳厚度的分析表明，与未处理的植入物相比，经高能离子处理的植入物的异物反应有所降低。反应的降低与聚氨酯表面的活化有关，这是由于在表面层形成了带有未键合价态的稠合芳香族簇，这些簇的边缘碳原子上存在未键合价态，并且生物体自身的蛋白质共价附着在植入物的活化表面上。因此，免疫细胞不会将涂有自身蛋白质的植入物表面识别为异物。由于在手术前对处理过的植入物进行储存，芳香结构边缘的自由价态失活，降低了表面活性并部分恢复了异物反应。为了在消除异物反应方面取得最大效果，建议在对植入物进行高能离子处理后立即进行手术，使处理过的表面与任何材料的接触最小化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/69b90ddf6956/materials-17-03833-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/037d0da229f5/materials-17-03833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/615354c962b0/materials-17-03833-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/8ce95800ea16/materials-17-03833-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/b0573dd1bb70/materials-17-03833-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/a4e0bbf41dad/materials-17-03833-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/13d70f569a85/materials-17-03833-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/273328d95a3a/materials-17-03833-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/0388b23b5ffd/materials-17-03833-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/9309e8d44103/materials-17-03833-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/11313228/69b90ddf6956/materials-17-03833-g013.jpg

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本文引用的文献

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Attachment of Fibrinogen on Ion Beam Treated Polyurethane.纤维蛋白原在离子束处理过的聚氨酯上的附着
Biomimetics (Basel). 2024 Apr 15;9(4):234. doi: 10.3390/biomimetics9040234.
2
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J Funct Biomater. 2023 Aug 17;14(8):432. doi: 10.3390/jfb14080432.
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Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction.
生物材料植入物表面的纤维蛋白聚合物会引发异物反应。
Biomaterials. 2021 Oct;277:121087. doi: 10.1016/j.biomaterials.2021.121087. Epub 2021 Aug 25.
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Biomaterial and cellular implants: foreign surfaces where immunity and coagulation meet.生物材料和细胞植入物：免疫与凝血相遇的外来表面。
Blood. 2022 Mar 31;139(13):1987-1998. doi: 10.1182/blood.2020007209.
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Polymeric Biomaterials for Medical Implants and Devices.用于医疗植入物和器械的高分子生物材料。
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Biomaterials: Foreign Bodies or Tuners for the Immune Response?生物材料：免疫反应的异物还是调谐器？
Int J Mol Sci. 2019 Feb 1;20(3):636. doi: 10.3390/ijms20030636.
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Invasive Intraneural Interfaces: Foreign Body Reaction Issues.侵入性神经内接口：异物反应问题。
Front Neurosci. 2017 Sep 6;11:497. doi: 10.3389/fnins.2017.00497. eCollection 2017.
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Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.骨组织工程支架：现状与新展望
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:1246-1262. doi: 10.1016/j.msec.2017.05.017. Epub 2017 May 5.
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Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response.工程化免疫调节生物材料以调节炎症反应。
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Synergistic interactions of blood-borne immune cells, fibroblasts and extracellular matrix drive repair in an in vitro peri-implant wound healing model.在体外种植体周围伤口愈合模型中，血源性免疫细胞、成纤维细胞和细胞外基质的协同相互作用驱动修复。
Sci Rep. 2016 Feb 17;6:21071. doi: 10.1038/srep21071.