Dueppers Philip, D'Oria Mario, Lepidi Sandro, Calvagna Cristiano, Zimmermann Alexander, Kopp Reinhard
Department of Vascular Surgery, University of Zurich (UZH), Raemistrasse 100, CH-8008 Zurich, Switzerland.
Department of Vascular Surgery, Kantonsspital St. Gallen, CH-9000 St. Gallen, Switzerland.
J Clin Med. 2024 Jul 23;13(15):4300. doi: 10.3390/jcm13154300.
Ruptured abdominal aortic aneurysms (rAAAs) are life-threatening and require emergent surgical therapy. Endovascular aortic repair for rupture (rEVAR) has become the leading strategy due to its minimal invasive approach with expected lower morbidity and mortality, especially in patients presenting with hemodynamic instability and relevant comorbidities. Following rEVAR, intraoperative angiography or early postinterventional computed tomography angiography have to exclude early type 1 or 3 endoleaks requiring immediate reintervention. Persistent type 2 endoleaks (T2ELs) after rEVAR, in contrast to elective cases, can cause possibly lethal situations due to continuing extravascular blood loss through the remaining aortic aneurysm rupture site. Therefore, early identification of relevant persistent T2ELs associated with continuous bleeding and hemodynamic instability and immediate management is mandatory in the acute postoperative setting following rEVAR. Different techniques and concepts for the occlusion of T2ELs after rEVAR are available, and most of them are also used for relevant T2ELs after elective EVAR. In addition to various interventional embolization procedures for persistent T2ELs, some patients require open surgical occlusion of T2EL-feeding arteries, abdominal compartment decompression or direct surgical patch occlusion of the aneurysm rupture site after rEVAR. So far, in the acute situation of rAAAs, indications for preemptive or intraoperative T2EL embolization during rEVAR have not been established. In the long term, persistent T2ELs after rEVAR can lead to continuous aneurysm expansion with the possible development of secondary proximal type I endoleaks and an increased risk of re-rupture requiring regular follow-up and early consideration for reintervention. To date, only very few studies have investigated T2ELs after rEVAR or compared outcomes with those from elective EVAR regarding the special aspects of persisting T2ELs. This narrative review is intended to present the current knowledge on the incidence, natural history, relevance and strategies for T2EL management after rEVAR.
腹主动脉瘤破裂(rAAA)危及生命,需要紧急手术治疗。由于其微创方法预期发病率和死亡率较低,尤其是对于出现血流动力学不稳定和相关合并症的患者,破裂性腹主动脉瘤的血管腔内修复术(rEVAR)已成为主要策略。rEVAR术后,术中血管造影或介入后早期计算机断层扫描血管造影必须排除需要立即再次干预的早期1型或3型内漏。与择期手术情况相比,rEVAR术后持续存在的2型内漏(T2EL)可能会因通过剩余腹主动脉瘤破裂部位持续的血管外失血而导致可能致命的情况。因此,在rEVAR术后的急性情况下,早期识别与持续出血和血流动力学不稳定相关的持续性T2EL并立即进行处理是必不可少的。rEVAR术后有多种用于封堵T2EL的技术和理念,其中大多数也用于择期EVAR术后的相关T2EL。除了针对持续性T2EL的各种介入栓塞程序外,一些患者在rEVAR术后需要开放手术封堵T2EL供血动脉、腹腔减压或直接手术修补动脉瘤破裂部位。到目前为止,在rAAA的急性情况下,rEVAR期间预防性或术中T2EL栓塞的指征尚未确立。从长远来看,rEVAR术后持续性T2EL可导致动脉瘤持续扩大,可能发展为继发性近端1型内漏,再破裂风险增加,需要定期随访并尽早考虑再次干预。迄今为止,只有极少数研究调查了rEVAR术后的T2EL,或就持续性T2EL的特殊方面将结果与择期EVAR的结果进行比较。本叙述性综述旨在介绍rEVAR术后T2EL的发生率、自然史、相关性及处理策略的当前知识。