M6A 在调控家畜经济性状中的作用研究进展。

Research Progress on the Role of M6A in Regulating Economic Traits in Livestock.

机构信息

State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China.

Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.

出版信息

Int J Mol Sci. 2024 Jul 31;25(15):8365. doi: 10.3390/ijms25158365.

DOI:10.3390/ijms25158365

PMID:39125935

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11313175/

Abstract

Reversible regulation of N6-methyladenosine (m6A) methylation of eukaryotic RNA via methyltransferases is an important epigenetic event affecting RNA metabolism. As such, m6A methylation plays crucial roles in regulating animal growth, development, reproduction, and disease progression. Herein, we review the latest research advancements in m6A methylation modifications and discuss regulatory aspects in the context of growth, development, and reproductive traits of livestock. New insights are highlighted and perspectives for the study of m6A methylation modifications in shaping economically important traits are discussed.

摘要

通过甲基转移酶对真核 RNA 的 N6-甲基腺嘌呤（m6A）甲基化进行可逆调控是影响 RNA 代谢的重要表观遗传事件。因此，m6A 甲基化在调节动物的生长、发育、繁殖和疾病进展中起着至关重要的作用。本文综述了 m6A 甲基化修饰的最新研究进展，并讨论了其在家畜生长、发育和繁殖性状方面的调控方面。本文还强调了新的见解，并讨论了研究 m6A 甲基化修饰在塑造经济重要性状方面的前景。