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氟脱氧葡萄糖正电子发射断层扫描在结节性多动脉炎诊断中的潜在应用价值:一例报告及文献综述

Possible usefulness of fluorodeoxyglucose positron emission tomography in diagnosing polyarteritis nodosa: A case report and literature review.

作者信息

Yukishima Toshitaka, Ohmura Shin-Ichiro, Yonezawa Haruka, Katayama Motoyuki, Otsuki Yoshiro, Miyamoto Toshiaki, Ogawa Noriyoshi

机构信息

Department of Rheumatology, Seirei Hamamatsu General Hospital, dvShizuoka, Japan.

Department of Radiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

出版信息

Mod Rheumatol Case Rep. 2025 Jan 16;9(1):137-142. doi: 10.1093/mrcr/rxae044.

Abstract

Polyarteritis nodosa (PAN) is a systemic rheumatic disease that affects medium-sized arteries. PAN is typically not associated with anti-neutrophil cytoplasmic antibodies and has no serological surrogate markers. Therefore, its diagnosis requires pathological findings. However, the positive rate of biopsy in diagnosing PAN is not high, and the biopsy area is often limited. Several investigators have reported the usefulness of imaging findings in diagnosing PAN, independent of pathological findings. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT has recently been approved for the diagnosis of large-vessel vasculitis in Japan. Several studies have also demonstrated the usefulness of FDG-PET/CT in diagnosing medium-vessel vasculitis. However, no studies have evaluated the usefulness of FDG-PET/CT for diagnosing PAN compared to other modalities, and it is not clear whether FDG-PET/CT is superior to other modalities for diagnosing PAN. Herein, we report a case of PAN and compare the usefulness of FDG-PET/CT with other modalities in diagnosing PAN.

摘要

结节性多动脉炎(PAN)是一种影响中等大小动脉的系统性风湿性疾病。PAN通常与抗中性粒细胞胞浆抗体无关,且没有血清学替代标志物。因此,其诊断需要病理结果。然而,活检在诊断PAN中的阳性率不高,且活检区域往往有限。一些研究者报告了影像学检查结果在诊断PAN中的有用性,与病理结果无关。18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)最近在日本已被批准用于诊断大血管血管炎。多项研究也证明了FDG-PET/CT在诊断中等血管血管炎中的有用性。然而,尚无研究评估FDG-PET/CT与其他检查方法相比在诊断PAN中的有用性,也不清楚FDG-PET/CT在诊断PAN方面是否优于其他检查方法。在此,我们报告一例PAN病例,并比较FDG-PET/CT与其他检查方法在诊断PAN中的有用性。

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