Department of Oncology, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, 510120, China.
The First Clinical Medical College, Nanchang University, Nanchang, 330006, China.
Cancer Lett. 2024 Oct 1;601:217159. doi: 10.1016/j.canlet.2024.217159. Epub 2024 Aug 14.
RNA modifications play a crucial role in cancer development, profoundly influencing various stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export, splicing, and translation in the cytoplasm. Among RNA modifications, RNA acC modification, also known as N4-acetylcytidine, stands out for its unique role in acetylation processes. Specific proteins regulate RNA acC modification, maintaining the dynamic and reversible nature of these changes. This review explores the molecular mechanisms and biological functions of RNA acC modification. It examines the intricate ways in which RNA acC modification influences the pathogenesis and progression of cancer. Additionally, the review provides an integrated overview of the current methodologies for detecting RNA acC modification. Exploring the potential applications of manipulating this modification suggests avenues for novel therapeutic strategies, potentially leading to more effective cancer treatments in the future.
RNA 修饰在癌症发展中起着至关重要的作用，深刻影响着 RNA 生命周期的各个阶段。这些阶段包括核处理、核输出、剪接和细胞质中的翻译。在 RNA 修饰中，RNA acC 修饰（也称为 N4-乙酰胞苷）因其在乙酰化过程中的独特作用而引人注目。特定的蛋白质调节 RNA acC 修饰，维持这些变化的动态和可逆性质。本综述探讨了 RNA acC 修饰的分子机制和生物学功能。它研究了 RNA acC 修饰影响癌症发病机制和进展的复杂方式。此外，该综述还提供了 RNA acC 修饰检测方法的综合概述。探索操纵这种修饰的潜在应用为新的治疗策略提供了途径，可能为未来更有效的癌症治疗铺平道路。
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