Steitieh Diala, Zaidi Alyssa, Xu Shirley, Cheung Jim W, Feldman Dmitriy N, Reisman Mark, Mallya Sonal, Paul Tracy K, Singh Harsimran S, Bergman Geoffrey, Vadaketh Krista, Naguib Mostafa, Minutello Robert M, Wong Shing Chiu, Amin Nivee P, Kim Luke K
Division of Cardiology, Department of Medicine, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York.
Department of Medicine, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York.
J Soc Cardiovasc Angiogr Interv. 2022 Jul 13;1(5):100398. doi: 10.1016/j.jscai.2022.100398. eCollection 2022 Sep-Oct.
Severe mitral regurgitation is a progressive disease associated with high morbidity and mortality, and frequent readmissions for heart failure. Surgical mitral valve repair or replacement has been the gold-standard treatment; however, advances in transcatheter edge-to-edge repair (TEER) have provided alternatives for high-risk surgical patients. There are no data on racial disparities in access to high-volume TEER centers.
Data on TEER hospitalizations from New York, New Jersey, Maryland, North Carolina, Washington, Colorado, Arizona, and Florida were analyzed using the State Inpatient Databases for 2016. The baseline characteristics of patients who underwent TEER at high- (≥25 procedures per year) and low-volume centers were identified. The association between race and the likelihood of undergoing TEER at high-volume centers was assessed. The secondary outcomes were mortality and the frequency of home discharges.
Of 1567 patients included in the analysis, 1129 underwent TEER at high-volume centers. Patients treated at high-volume centers had a higher prevalence of chronic kidney disease and congestive heart failure. Black and Hispanic patients were 59% (adjusted odds ratio [OR], 0.41; < .001) and 51% (adjusted OR, 0.49; < .001) less likely to undergo TEER at high-volume centers, respectively, compared with White patients. Hispanic patients were 3 times more likely to die during index admission than White patients (adjusted OR, 3.32; = .027). There was geographic clustering of TEER centers, and a higher ratio of White patients to minority patients in zip codes with high-volume TEER centers.
Racial minorities patients, particularly Black and Hispanic patients, are less likely to undergo TEER at high-volume centers. Hispanic patients experience higher rates of in-hospital mortality after TEER than White patients.
重度二尖瓣反流是一种进行性疾病,与高发病率、高死亡率以及因心力衰竭频繁再次入院相关。外科二尖瓣修复或置换一直是金标准治疗方法;然而,经导管缘对缘修复术(TEER)的进展为高风险手术患者提供了替代方案。目前尚无关于获得高容量TEER中心治疗方面种族差异的数据。
利用2016年的州住院数据库分析了来自纽约、新泽西、马里兰州、北卡罗来纳州、华盛顿州、科罗拉多州、亚利桑那州和佛罗里达州的TEER住院数据。确定了在高容量(每年≥25例手术)和低容量中心接受TEER治疗的患者的基线特征。评估了种族与在高容量中心接受TEER治疗可能性之间的关联。次要结局是死亡率和出院回家的频率。
在纳入分析的1567例患者中,1129例在高容量中心接受了TEER治疗。在高容量中心接受治疗的患者慢性肾脏病和充血性心力衰竭的患病率更高。与白人患者相比,黑人和西班牙裔患者在高容量中心接受TEER治疗的可能性分别低59%(调整优势比[OR],0.41;P<0.001)和51%(调整OR,0.49;P<0.001)。西班牙裔患者在首次入院期间死亡的可能性是白人患者的3倍(调整OR,3.32;P=0.027)。TEER中心存在地理聚集现象,在高容量TEER中心所在的邮政编码区域,白人患者与少数族裔患者的比例更高。
少数族裔患者,尤其是黑人和西班牙裔患者,在高容量中心接受TEER治疗的可能性较小。西班牙裔患者在TEER术后的院内死亡率高于白人患者。