Mu Yuzhu, Pan Ting, Chen Lingling
Department of Dermatology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215000, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Aug 6;17:1789-1792. doi: 10.2147/CCID.S467026. eCollection 2024.
Vitiligo and alopecia areata are both autoimmune skin diseases, and the chances of co-occurrence are very low. Conventional treatments often include glucocorticoids, which have many adverse reactions with long-term use and are difficult to achieve satisfactory results. Upadacitinib has been found to be effective in both vitiligo and alopecia areata due to partial overlap in pathogenic pathways. We report the successful treatment of vitiligo combined with alopecia areata in a nine-year-old child with upadacitinib in combination with UVB. The area of vitiligo and alopecia areata decreased significantly, and satisfactory results were obtained. It provides a new idea for the treatment of vitiligo complicated with alopecia areata in children.
白癜风和斑秃均为自身免疫性皮肤病，二者同时出现的几率很低。传统治疗方法通常包括使用糖皮质激素，长期使用会产生诸多不良反应，且难以取得满意疗效。由于致病途径存在部分重叠，已发现乌帕替尼对白癜风和斑秃均有效。我们报告了一名9岁儿童使用乌帕替尼联合紫外线B成功治疗白癜风合并斑秃的病例。白癜风和斑秃的面积显著减小，取得了满意的效果。这为儿童白癜风合并斑秃的治疗提供了新思路。
