Zhu Ying, Zeng Tao, Huai Hongbo, Zhu Tong, Huang Ying, Li Jing, Lin Jian
Department of Pain Medicine, Kunshan Integrated TCM and Western Medicine Hospital, Kunshan, 215332, People's Republic of China.
Rehabilitation Department, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, People's Republic of China.
J Pain Res. 2024 Aug 6;17:2585-2595. doi: 10.2147/JPR.S471816. eCollection 2024.
This retrospective study was to investigate the efficacy of Gasserian ganglion pulsed radiofrequency therapy (PRF) combined with low-dose morphine injection in the treatment of refractory ophthalmic herpetic neuralgia.
A total of 40 intractable ophthalmic herpetic neuralgia patients who received Gasserian ganglion PRF therapy in Pain Department of Nanjing Drum Tower Hospital were retrospectively analysed, with an average age of 70.2 ± 8.5 years and an average disease course of 30 (30, 60) days. According to different interventions, they were divided into two groups: Group A, 19 patients who received Gasserian ganglion PRF therapy combined with 0.2 mg morphine injection via puncture needle; Group B, 21 patients who received only Gasserian ganglion PRF therapy. Data related to the length of hospital stay and associated costs, numerical rating scale scores (NRS), intravenous morphine and oral oxycodone doses during hospitalization, Short form McGill pain questionnaire and Pittsburgh sleep quality index (PSI), and conditions of opioid use and postherpetic neuralgia after discharge were collected in the two groups. SPSS 25.0 was used to perform statistical analysis on data.
The hospital stay, hospitalization costs, and oxycodone dosages for Group A were lower than those for Group B (p = 0.02, p = 0.015 and p = 0.023, respectively). The proportion of patients in group A still taking oral opioids 1 month after discharge and experiencing postherpetic neuralgia 6 months after the onset was lower than that in group B (p = 0.004 and p = 0.049). The NRS upon discharge, as well as the McGill and PSQI scores at the time of discharge and at 1, 3, 6 and 12 months post-discharge, were all significantly reduced compared to those measured upon admission in two groups (p = 0.000).
Gasserian ganglion PRF therapy combined with low-dose morphine injection offers an alternative option for managing intractable herpetic neuralgia and prevention of postherpetic neuralgia in ocular branches.
ChiCTR2300073281.
本回顾性研究旨在探讨半月神经节脉冲射频治疗（PRF）联合小剂量吗啡注射治疗难治性眼部带状疱疹神经痛的疗效。
回顾性分析南京鼓楼医院疼痛科接受半月神经节PRF治疗的40例难治性眼部带状疱疹神经痛患者，平均年龄70.2±8.5岁，平均病程30（30，60）天。根据不同干预措施，将其分为两组：A组，19例患者接受半月神经节PRF治疗并通过穿刺针注射0.2mg吗啡；B组，21例患者仅接受半月神经节PRF治疗。收集两组患者的住院时间、相关费用、数字评分量表评分（NRS）、住院期间静脉注射吗啡和口服羟考酮剂量、简化麦吉尔疼痛问卷和匹兹堡睡眠质量指数（PSI），以及出院后阿片类药物使用情况和带状疱疹后神经痛情况。采用SPSS 25.0对数据进行统计分析。
A组的住院时间、住院费用和羟考酮剂量均低于B组（分别为p = 0.02、p = 0.015和p = 0.023）。A组出院后1个月仍服用口服阿片类药物且发病后6个月出现带状疱疹后神经痛的患者比例低于B组（分别为p = 0.004和p = 0.049）。与入院时相比，两组出院时的NRS以及出院时、出院后1、3、6和12个月时的麦吉尔和PSI评分均显著降低（p = 0.000）。
半月神经节PRF治疗联合小剂量吗啡注射为难治性带状疱疹神经痛的管理和预防眼部分支带状疱疹后神经痛提供了一种替代选择。
ChiCTR2300073281。
