Department of Endocrinology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Jinbi Road, Xishan District, Kunming, 650032, Yunnan Province, China.
BMC Endocr Disord. 2024 Aug 12;24(1):149. doi: 10.1186/s12902-024-01679-1.
Type 1 diabetes mellitus (T1DM) is well-known to trigger a disruption of lipid metabolism. This study aimed to compare lipid profile changes in T1DM patients after achieving glucose control and explore the underlying mechanisms. In addition, we seek to identify novel lipid biomarkers associated with T1DM under conditions of glycemic control.
A total of 27 adults with T1DM (age: 34.3 ± 11.2 yrs) who had maintained glucose control for over a year, and 24 healthy controls (age: 35.1 + 5.56 yrs) were recruited. Clinical characteristics of all participants were analyzed and plasma samples were collected for untargeted lipidomic analysis using mass spectrometry.
We identified 594 lipid species from 13 major classes. Differential analysis of plasma lipid profiles revealed a general decline in lipid levels in T1DM patients with controlled glycemic levels, including a notable decrease in triglycerides (TAGs) and diglycerides (DAGs). Moreover, these T1DM patients exhibited lower levels of six phosphatidylcholines (PCs) and three phosphatidylethanolamines (PEs). Random forest analysis determined DAG(14:0/20:0) and PC(18:0/20:3) to be the most prominent plasma markers of T1DM under glycemic control (AUC = 0.966).
The levels of all metabolites from the 13 lipid classes were changed in T1DM patients under glycemic control, with TAGs, DAGs, PCs, PEs, and FFAs demonstrating the most significant decrease. This research identified DAG(14:0/20:0) and PC(18:0/20:3) as effective plasma biomarkers in T1DM patients with controled glycemic levels.
1 型糖尿病（T1DM）众所周知会引发脂质代谢紊乱。本研究旨在比较血糖控制后 T1DM 患者的血脂谱变化，并探讨潜在机制。此外，我们试图在血糖控制条件下鉴定与 T1DM 相关的新型脂质生物标志物。
共纳入 27 名血糖控制时间超过 1 年的 T1DM 成年患者（年龄：34.3±11.2 岁）和 24 名健康对照者（年龄：35.1+5.56 岁）。分析所有参与者的临床特征，并采集血浆样本，使用质谱法进行非靶向脂质组学分析。
我们从 13 个主要类别中鉴定出 594 种脂质。对 T1DM 患者和健康对照者的血浆脂质谱进行差异分析，发现血糖控制良好的 T1DM 患者的脂质水平普遍下降，包括甘油三酯（TAGs）和二甘油酯（DAGs）显著下降。此外，这些 T1DM 患者还表现出六种磷脂酰胆碱（PCs）和三种磷脂酰乙醇胺（PEs）水平降低。随机森林分析确定 DAG(14:0/20:0)和 PC(18:0/20:3)是血糖控制下 T1DM 最显著的血浆标志物（AUC=0.966）。
血糖控制下 T1DM 患者的 13 种脂质类别中的所有代谢物水平均发生改变，其中 TAGs、DAGs、PCs、PEs 和 FFAs 下降最显著。本研究鉴定出 DAG(14:0/20:0)和 PC(18:0/20:3)作为血糖控制良好的 T1DM 患者的有效血浆生物标志物。
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