J Cardiovasc Nurs. 2024;39(3):E80-E85. doi: 10.1097/JCN.0000000000001075.
Incidence of cognitive impairment and its consequences have not been fully examined in heart failure (HF).
The aim of this study was to examine associations of HF with cognitive decline, frequencies and risks of, and time-to-develop mild cognitive impairment (MCI) or dementia during 15-year follow-up.
For this retrospective cohort study, data were retrieved from the National Alzheimer's Coordinating Center. Cognitive decline was assessed using the Uniform Data Set neuropsychological battery. Development of MCI and dementia was assessed using clinically diagnosed cognitive status.
Compared with participants without HF (n = 12 904), participants with HF (n = 256) had more decline in attention, executive function, and memory while controlling for covariates including apolipoprotein E4. Participants with HF developed MCI or dementia more frequently (44.9% vs 34.4%), developed dementia faster from normal cognition, and had a lower risk of dementia from MCI after controlling for covariates (hazard ratio, 0.71) than participants without HF.
Heart failure was associated with accelerated cognitive decline.
心力衰竭（HF）患者的认知障碍发生率及其后果尚未得到充分研究。
本研究旨在探讨 HF 与认知能力下降、认知障碍的频率和风险以及在 15 年随访期间发展为轻度认知障碍（MCI）或痴呆的时间之间的关系。
本回顾性队列研究的数据来自国家阿尔茨海默病协调中心。使用统一数据组神经心理学电池评估认知能力下降。使用临床诊断的认知状态评估 MCI 和痴呆的发展。
与无 HF 参与者（n=12904）相比，HF 参与者（n=256）在控制包括载脂蛋白 E4 在内的混杂因素后，注意力、执行功能和记忆力的下降更为明显。HF 参与者发生 MCI 或痴呆的频率更高（44.9%比 34.4%），从正常认知到痴呆的发展速度更快，并且在控制混杂因素后，从 MCI 到痴呆的风险较低（危险比，0.71）。
心力衰竭与认知能力加速下降有关。
