Champalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, Portugal.
Champalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, Portugal.
Neuron. 2024 Oct 9;112(19):3329-3342.e7. doi: 10.1016/j.neuron.2024.07.009. Epub 2024 Aug 12.
The role of experience in the organization of cortical feedback (FB) remains unknown. We measured the effects of manipulating visual experience on the retinotopic specificity of supragranular and infragranular projections from the lateromedial (LM) visual area to layer (L)1 of the mouse primary visual cortex (V1). LM inputs were, on average, retinotopically matched with V1 neurons in normally and dark-reared mice, but visual exposure reduced the fraction of spatially overlapping inputs to V1. FB inputs from L5 conveyed more surround information to V1 than those from L2/3. The organization of LM inputs from L5 depended on their orientation preference and was disrupted by dark rearing. These observations were recapitulated by a model where visual experience minimizes receptive field overlap between LM inputs and V1 neurons. Our results provide a mechanism for the dependency of surround modulations on visual experience and suggest how expected interarea coactivation patterns are learned in cortical circuits.
经验在皮层反馈(FB)组织中的作用尚不清楚。我们测量了操纵视觉经验对从中线(LM)视觉区域到小鼠初级视觉皮层(V1)第 1 层(L1)的超颗粒和颗粒下投射的视网膜特异性的影响。LM 输入在正常和暗适应小鼠中与 V1 神经元的视网膜是匹配的,但视觉暴露减少了与 V1 重叠的输入的分数。来自 L5 的 FB 输入比来自 L2/3 的输入向 V1 传递更多的周围信息。来自 L5 的 LM 输入的组织取决于它们的方向偏好,并且被暗适应破坏。该模型再现了这些观察结果,其中视觉经验最小化了 LM 输入和 V1 神经元之间的感受野重叠。我们的结果为周围调制对视觉经验的依赖性提供了一种机制,并表明了在皮质电路中如何学习预期的区域间共激活模式。