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高龄老人痴呆症的预测因素:来自北莱茵-威斯特法伦州(NRW80+)高龄老人生活质量和主观幸福感代表性调查的纵向研究结果。

Predictors of dementia among the oldest old: longitudinal findings from the representative "survey on quality of life and subjective well-being of the very old in North Rhine-Westphalia (NRW80+)".

机构信息

Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg Center for Health Economics, Hamburg, Germany.

Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.

出版信息

BMC Geriatr. 2024 Aug 13;24(1):680. doi: 10.1186/s12877-024-05255-z.

Abstract

BACKGROUND/AIMS: Our current study aimed to investigate the determinants of dementia among the oldest old using longitudinal data from a representative sample covering both community-dwelling and institutionalized individuals.

METHODS/DESIGN: Longitudinal representative data were taken from the "Survey on quality of life and subjective well-being of the very old in North Rhine-Westphalia (NRW80+)" that surveyed community-dwelling and institutionalized individuals aged 80 years and above (n = 1,296 observations in the analytic sample), living in North Rhine-Westphalia (most populous state of Germany). The established DemTect was used to measure cognitive impairment (i.e., probable dementia). A logistic random effects model was used to examine the determinants of probable dementia.

RESULTS

The mean age was 86.3 years (SD: 4.2 years). Multiple logistic regressions revealed that a higher likelihood of probable dementia was positively associated with lower education (e.g., low education compared to medium education: OR: 3.31 [95% CI: 1.10-9.98]), a smaller network size (OR: 0.87 [95% CI: 0.79-0.96]), lower health literacy (OR: 0.29 [95% CI: 0.14-0.60]), and higher functional impairment (OR: 13.45 [3.86-46.92]), whereas it was not significantly associated with sex, age, marital status, loneliness, and depressive symptoms in the total sample. Regressions stratified by sex were also reported.

DISCUSSION

Our study identified factors associated with dementia among the oldest old. This study extends current knowledge by using data from the oldest old; and by presenting findings based on longitudinal, representative data (also including individuals residing in institutionalized settings).

CONCLUSIONS

Efforts to increase, among other things, formal education, network size, and health literacy may be fruitful in postponing dementia, particularly among older women. Developing health literacy programs, for example, may be beneficial to reduce the burden associated with dementia.

摘要

背景/目的:本研究旨在利用一项覆盖社区居住和机构居住个体的代表性纵向数据,探究高龄老人痴呆症的决定因素。

方法/设计:本研究使用了“北莱茵-威斯特法伦州高龄老人生活质量和主观幸福感调查(NRW80+)”的纵向代表性数据,该调查涵盖了 80 岁及以上的社区居住和机构居住个体(分析样本中共有 1296 个观察值),生活在北莱茵-威斯特法伦州(德国人口最多的州)。采用既定的 DemTect 量表来衡量认知障碍(即可能的痴呆症)。使用逻辑随机效应模型来检验可能痴呆症的决定因素。

结果

平均年龄为 86.3 岁(标准差:4.2 岁)。多变量逻辑回归显示,较高的可能痴呆症发病几率与较低的教育程度(例如,低教育程度与中等教育程度相比:比值比:3.31[95%置信区间:1.10-9.98])、较小的社交网络规模(比值比:0.87[95%置信区间:0.79-0.96])、较低的健康素养(比值比:0.29[95%置信区间:0.14-0.60])和更高的功能障碍(比值比:13.45[3.86-46.92])呈正相关,而与性别、年龄、婚姻状况、孤独感和抑郁症状在总样本中无显著相关性。也报告了按性别分层的回归结果。

讨论

本研究确定了高龄老人痴呆症的相关因素。本研究通过使用来自高龄老人的数据以及通过呈现基于纵向、代表性数据(包括居住在机构环境中的个体)的研究结果,扩展了当前的知识。

结论

除其他外,增加正规教育、社交网络规模和健康素养的努力可能有助于延缓痴呆症的发生,尤其是在老年女性中。例如,开展健康素养计划可能有助于减轻与痴呆症相关的负担。

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