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一种基于诱导多能干细胞的毛囊发育与再生方法。

An induced pluripotent stem cell-based approach for hair follicle development and regeneration.

作者信息

Sivamani Poornima, Rajendran Ramya Lakshmi, Gangadaran Prakash, Ahn Byeong-Cheol

机构信息

Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, India.

Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

出版信息

Regen Ther. 2024 Jul 23;26:502-507. doi: 10.1016/j.reth.2024.07.005. eCollection 2024 Jun.

DOI:10.1016/j.reth.2024.07.005
PMID:39140101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11321309/
Abstract

Because hair loss is a common concern for many individuals, potential regenerative therapies of hair follicles have been extensively researched. Induced pluripotent stem cells (iPSCs) are a promising avenue for hair follicle regeneration. This review explores current iPSC-based approaches and highlights their potential applications and challenges in hair restoration. The principles of iPSC technology, iPSC differentiation into hair follicle precursor cells, and potential clinical implications for hair follicle regeneration are also discussed. This overview of iPSCs and their applications aims to contribute to our understanding of their role in hair restoration and potential future therapeutic applications.

摘要

由于脱发是许多人普遍关注的问题，毛囊的潜在再生疗法已得到广泛研究。诱导多能干细胞（iPSC）是毛囊再生的一个有前景的途径。本综述探讨了当前基于iPSC的方法，并强调了它们在毛发修复中的潜在应用和挑战。还讨论了iPSC技术的原理、iPSC分化为毛囊前体细胞以及对毛囊再生的潜在临床意义。对iPSC及其应用的概述旨在促进我们对它们在毛发修复中的作用以及未来潜在治疗应用的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ed/11321309/4621aac338ea/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ed/11321309/4621aac338ea/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ed/11321309/4621aac338ea/gr1.jpg

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JAMA. 2024 May 28;331(20):1698. doi: 10.1001/jama.2024.6727.
2
Human-Induced Pluripotent Stem Cells in Plastic and Reconstructive Surgery.人诱导多能干细胞在整形与重建外科中的应用。
Int J Mol Sci. 2024 Feb 3;25(3):1863. doi: 10.3390/ijms25031863.
3
Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector.利用维生素 D 受体表达腺病毒载体治疗Ⅱ型佝偻病模型大鼠的脱发症。
Sci Rep. 2023 Oct 28;13(1):18528. doi: 10.1038/s41598-023-45594-2.
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Effects of oxytocin on the hair growth ability of dermal papilla cells.催产素对真皮乳头细胞毛发生长能力的影响。
Sci Rep. 2023 Oct 20;13(1):15587. doi: 10.1038/s41598-023-40521-x.
5
Editorial: Advances in iPSC technology for disease modeling and therapeutic applications.社论：用于疾病建模和治疗应用的诱导多能干细胞技术进展
Front Cell Dev Biol. 2023 Jul 31;11:1261279. doi: 10.3389/fcell.2023.1261279. eCollection 2023.
6
iPSC-based approach for human hair follicle regeneration.基于诱导多能干细胞的人类毛囊再生方法。
Front Cell Dev Biol. 2023 May 30;11:1149050. doi: 10.3389/fcell.2023.1149050. eCollection 2023.
7
Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss.毛发生长周期与脱发的综合及机制研究方法
J Clin Med. 2023 Jan 23;12(3):893. doi: 10.3390/jcm12030893.
8
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