Xiang Feifan, Zhang Yue, Tan Xiaoqi, Yan Yuanzhuo, Liu Huipan, Ma Wenzhe, Chen Yue
The State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, China.
Department of Orthopedic, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Front Oncol. 2024 Jul 31;14:1428498. doi: 10.3389/fonc.2024.1428498. eCollection 2024.
Ga labeled DOTA-Ibandronate (Ga-DOTA-IBA) positron emission tomography/computed tomography (PET/CT), is a novel bone-targeting imaging tracer and promising diagnostic method for bone metastases detection. Therefore, this study aimed to compare Ga-DOTA-IBA PET/CT to the Tc-MDP whole-body bone scan (WBBS) for detecting bone metastases in breast cancer (BC).
In this prospective study, 45 women with BC underwent imaging via Ga-DOTA-IBA PET/CT and Tc-MDP WBBS. Clinical and demographic information as well as BC imaging features were recorded. The two methods were compared in terms of their detection rate for bone metastases and the number of lesions.
The 45 women were aged 53.5 ± 11.0 years. The bone metastases detection rate with Ga-DOTA-IBA PET/CT was 100% (45/45) and with Tc-MDP WBBS was 95.6% (43/45). A total of 546 bone metastases lesions were detected. The lesion detection rate using Ga-DOTA-IBA PET/CT was 100% (546/546) and using Tc-MDP WBBS was 67.8% (370/546). More lesions were found at each site via Ga-DOTA-IBA than via Tc-MDP WBBS.
Ga-DOTA-IBA PET/CT is a more sensitive method than Tc-MDP WBBS for assessing bone metastases in BC and may therefore represent a useful imaging technique for bone metastases, while offering a visual basis for Lu-DOTA-IBA diagnosis and therapy response assessments for BC. Further validation using a broader study cohort is warranted to confirm these findings.
https://www.chictr.org.cn/showproj.html?proj=170163, identifier ChiCTR2200064487.
镓标记的DOTA-伊班膦酸盐（Ga-DOTA-IBA）正电子发射断层扫描/计算机断层扫描（PET/CT）是一种新型的骨靶向成像示踪剂，也是用于检测骨转移的有前景的诊断方法。因此，本研究旨在比较Ga-DOTA-IBA PET/CT与锝-亚甲基二膦酸盐全身骨扫描（WBBS）在检测乳腺癌（BC）骨转移方面的效果。
在这项前瞻性研究中，45例乳腺癌女性患者接受了Ga-DOTA-IBA PET/CT和锝-亚甲基二膦酸盐WBBS检查。记录临床和人口统计学信息以及乳腺癌的影像学特征。比较了两种方法在骨转移检测率和病变数量方面的差异。
45例女性患者的年龄为53.5±11.0岁。Ga-DOTA-IBA PET/CT的骨转移检测率为100%（45/45），锝-亚甲基二膦酸盐WBBS的检测率为95.6%（43/45）。共检测到546处骨转移病变。使用Ga-DOTA-IBA PET/CT的病变检测率为100%（546/546），使用锝-亚甲基二膦酸盐WBBS的检测率为67.8%（370/546）。通过Ga-DOTA-IBA在每个部位发现的病变比通过锝-亚甲基二膦酸盐WBBS更多。
对于评估乳腺癌骨转移，Ga-DOTA-IBA PET/CT比锝-亚甲基二膦酸盐WBBS更敏感，因此可能是一种用于骨转移的有用成像技术，同时为乳腺癌的镥-DOTA-IBA诊断和治疗反应评估提供视觉依据。有必要使用更广泛的研究队列进行进一步验证以证实这些发现。
https://www.chictr.org.cn/showproj.html?proj=170163，标识符ChiCTR2200064487。
