[林奇综合征患者结直肠癌发生中的性别特异性差异——一项系统综述]
[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review].
作者信息
Dohmen Jonas, Sommer Nils, van Beekum Katrin, Nattermann Jacob, Engel Christoph, Kalff Jörg C, Hüneburg Robert, Vilz Tim O
机构信息
Klinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.
Nationales Zentrum für erbliche Tumorerkrankungen, Universitätsklinikum Bonn, Bonn, Deutschland.
出版信息
Chirurgie (Heidelb). 2024 Sep;95(9):696-708. doi: 10.1007/s00104-024-02159-x. Epub 2024 Aug 15.
BACKGROUND
Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.
OBJECTIVE
This systematic review aims to investigate gender-specific differences in CRC development among LS patients.
MATERIAL AND METHODS
A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.
RESULTS
Men have a higher risk of CRC and develop CRC earlier compared to women.
CONCLUSION
These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.
背景
林奇综合征（LS）是最常见的遗传性肿瘤综合征，与结直肠癌（CRC）风险增加相关。虽然在患者监测中会考虑基因特异性和年龄特异性差异，但许多研究报告了CRC发生中的性别特异性风险，但记录并不一致。
目的
本系统评价旨在调查LS患者中CRC发生的性别特异性差异。
材料与方法
按照PRISMA 2020指南在PubMed、Ovid、Cochrane图书馆和Web of Science数据库中进行系统文献检索。共筛选688项研究，41项符合纳入标准。
结果
与女性相比，男性患CRC的风险更高，且发病更早。
结论
这些发现表明LS患者中CRC风险存在性别特异性差异，尽管目前这些差异并不足以证明需要采取单独的监测策略。
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