微生物组修饰用于治疗共生失调疾病的个体化治疗。
Microbiome modification for personalized treatment of dysbiotic diseases.
机构信息
Center for Gastrointestinal Biology and Disease, University of North Carolina - Chapel Hill, Chapel Hill, NC 27517, USA.
出版信息
Cell Host Microbe. 2024 Aug 14;32(8):1219-1224. doi: 10.1016/j.chom.2024.07.023.
PMID:39146793
Abstract
Fecal microbial transplantation (FMT) for inflammatory diseases or refractory immune checkpoint inhibitor therapy is less effective than for preventing recurrent Clostridioides difficile infection. This commentary outlines strategies to use biomarkers of successful FMT to guide newer approaches to restore microbial homeostasis in individuals with dysbiosis-mediated inflammation.
摘要
粪便微生物移植（FMT）治疗炎症性疾病或难治性免疫检查点抑制剂治疗的效果不如预防复发性艰难梭菌感染。本文述评提出了利用 FMT 成功的生物标志物来指导新方法的策略，以恢复由菌群失调引起的炎症患者的微生物稳态。
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