Gordon J L
Adv Exp Med Biol. 1985;192:419-25. doi: 10.1007/978-1-4615-9442-0_30.
The pathways through which endothelial cells can modulate platelet reactivity (whether directly via the secretion of agents that affect platelet function or indirectly through the regulation of coagulation or vascular tone) are sufficiently varied and complex that the direction of individual reactions can be altered as the homeostatic balance requires--in other words, the balance can be shifted in favour of activation or inhibition depending on circumstances. For example, endothelium has the capacity to express pro- or anticoagulant activities, and to release or inactivate agents that either promote or inhibit platelet aggregation. The role of endothelial cells in modulating platelet function is important, complex and as yet poorly understood, but our understanding of the processes involved has advanced greatly over the past few years and continues to increase.
内皮细胞调节血小板反应性的途径（无论是直接通过分泌影响血小板功能的因子，还是间接通过调节凝血或血管张力）多种多样且十分复杂，以至于个体反应的方向可根据体内平衡的需要而改变——换句话说，根据具体情况，平衡可向激活或抑制的方向偏移。例如，内皮具有表达促凝或抗凝活性的能力，以及释放或灭活促进或抑制血小板聚集的因子的能力。内皮细胞在调节血小板功能中的作用很重要、很复杂且目前仍知之甚少，但在过去几年里，我们对相关过程的理解有了很大进展，并且还在不断加深。
