Lei Sujuan, Liu Chen, Zheng Tian-Xiang, Fu Wenguang, Huang Mei-Zhou
Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, Academician (Expert) Workstation of Sichuan Province, Department of General Surgery (Hepatopancreatobiliary Surgery), Chongqing, Sichuan, China.
Front Pharmacol. 2024 Aug 1;15:1430293. doi: 10.3389/fphar.2024.1430293. eCollection 2024.
Oxidative balance plays a pivotal role in physiological homeostasis, and many diseases, particularly age-related conditions, are closely associated with oxidative imbalance. While the strategic role of oxidative regulation in various diseases is well-established, the specific involvement of oxidative stress in atherosclerosis remains elusive. Atherosclerosis is a chronic inflammatory disorder characterized by plaque formation within the arteries. Alterations in the oxidative status of vascular tissues are linked to the onset, progression, and outcome of atherosclerosis. This review examines the role of redox signaling in atherosclerosis, including its impact on risk factors such as dyslipidemia, hyperglycemia, inflammation, and unhealthy lifestyle, along with dysregulation, vascular homeostasis, immune system interaction, and therapeutic considerations. Understanding redox signal transduction and the regulation of redox signaling will offer valuable insights into the pathogenesis of atherosclerosis and guide the development of novel therapeutic strategies.
氧化平衡在生理稳态中起着关键作用，许多疾病，尤其是与年龄相关的病症，都与氧化失衡密切相关。虽然氧化调节在各种疾病中的战略作用已得到充分证实，但氧化应激在动脉粥样硬化中的具体作用仍不明确。动脉粥样硬化是一种慢性炎症性疾病，其特征是动脉内形成斑块。血管组织氧化状态的改变与动脉粥样硬化的发生、发展和结局有关。本综述探讨了氧化还原信号在动脉粥样硬化中的作用，包括其对血脂异常、高血糖、炎症和不健康生活方式等危险因素的影响，以及失调、血管稳态、免疫系统相互作用和治疗方面的考虑。了解氧化还原信号转导和氧化还原信号的调节将为动脉粥样硬化的发病机制提供有价值的见解，并指导新治疗策略的开发。
