Böhm Lea, Schirm Nina, Zimmermann Tanja, Meyer Nadia, von Versen-Höynck Frauke
Department of Gynecology and Obstetrics, AG Reproductive Medicine and Molecular Perinatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Department of Psychosomatics and Psychotherapy, Hannover Medical School, Hannover, Germany.
Arch Gynecol Obstet. 2025 Apr;311(4):951-963. doi: 10.1007/s00404-024-07689-7. Epub 2024 Aug 17.
The aim of this study was to collect and analyze information from pregnancies of organ transplanted women and partners of organ transplanted men. The goal was to enhance counseling regarding pregnancy planning and management and to enable more targeted monitoring to improve maternal and child health.
In this retrospective, multicenter cohort study, women and men aged 18 to 45 who had undergone organ transplantation in Germany, Austria, and Switzerland were surveyed about their pregnancies before and after transplantation by using a self-developed questionnaire.
Even through transplanted women planned their pregnancies more carefully than before transplantation, they still experienced more pregnancy complications afterward. The live birth rate for pregnancies of partners of transplanted men, especially men who received a thoracic organ, was lower compared to before transplantation. Furthermore, this study showed that pregnancies of the partners of male transplant recipients occurred significantly less by spontaneous conception in comparison to pregnancies of transplanted women.
Pregnancies after organ transplantation are possible but associated with an increased risk of pregnancy complications. Therefore, early counseling for transplanted women and men who wish to have children, along with extensive monitoring during pregnancy, is necessary.
本研究旨在收集并分析器官移植女性妊娠及器官移植男性伴侣妊娠的相关信息。目标是加强有关妊娠计划和管理的咨询服务，并进行更具针对性的监测，以改善母婴健康。
在这项回顾性多中心队列研究中，通过使用自行编制的问卷，对德国、奥地利和瑞士年龄在18至45岁之间接受过器官移植的女性和男性进行了关于移植前后妊娠情况的调查。
尽管器官移植女性在妊娠计划上比移植前更加谨慎，但她们之后仍经历了更多的妊娠并发症。移植男性伴侣的妊娠活产率，尤其是接受胸器官移植的男性伴侣，相较于移植前有所降低。此外，本研究表明，与器官移植女性的妊娠相比，男性移植受者伴侣的妊娠通过自然受孕的情况明显更少。
器官移植后妊娠是有可能的，但伴有妊娠并发症风险增加。因此，有必要对希望生育的器官移植女性和男性进行早期咨询，并在孕期进行广泛监测。
