Bermont Anton, Abu-Freha Naim, Cohen Daniel L, Abu-Kaf Heba, Abu Juma Ali, Abu Galion Fahmi, Aminov Refael, Shirin Haim
The Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, School of Medicine Faculty of Medical and Health Sciences, Tel Aviv University, Zerifin, Israel.
Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Dig Liver Dis. 2025 Jan;57(1):220-224. doi: 10.1016/j.dld.2024.07.037. Epub 2024 Aug 17.
Gastrointestinal angiodysplasia (GIAD) is a rare diagnosis among the general population. We aimed to identify risk factors for GIADs and to determine the frequency rate in the general population.
A population-based retrospective study was performed including patients diagnosed with upper (stomach/duodenum) or lower (small bowel/colon) GIADs based on diagnostic codes from a large health maintenance organization. Control groups were matched for age and gender. Additional data including demographics, comorbidities, malignancies, and medications were collected.
991 upper GIADs and 3336 lower GIADs were included, compared to 7217 and 32,802 controls. The overall prevalence of GIAD was 0.092 %. 88 % of the upper and 85 % of the lower GIADs were diagnosed at ages ≥60, peaking at a prevalence of 0.37 % for ages 71-80. The most significant risk factors for GIADs included liver cirrhosis (OR 4.0 for lower GIAD and OR 7.0 for upper GIAD, p < 0.001), hypertension (OR 2.3 for lower GIAD and OR 2.8 for upper GIAD, p < 0.001) and aortic stenosis (OR 2.8 for lower GIAD and OR 2.0 for upper GIAD, p < 0.001). Other significant risk factors included ischemic heart disease, chronic renal failure, female gender, and chronic obstructive pulmonary disease. Interestingly, both upper and lower GIADs were found to be significantly less frequent in patients with malignancy.
Identification of the clinical conditions and demographic factors associated with GIAD may improve our understanding of the etiology and the optimal treatment modalities for this rare condition.
胃肠道血管发育异常（GIAD）在普通人群中是一种罕见的诊断。我们旨在确定GIAD的危险因素，并确定普通人群中的发病率。
基于人群的回顾性研究，纳入了根据大型健康维护组织的诊断编码被诊断为上消化道（胃/十二指肠）或下消化道（小肠/结肠）GIAD的患者。对照组按年龄和性别匹配。收集了包括人口统计学、合并症、恶性肿瘤和药物治疗等额外数据。
纳入了991例上消化道GIAD和3336例下消化道GIAD，与之相比，对照组分别为7217例和32802例。GIAD的总体患病率为0.092%。88%的上消化道GIAD和85%的下消化道GIAD在60岁及以上被诊断，在71-80岁患病率最高，为0.37%。GIAD最显著的危险因素包括肝硬化（下消化道GIAD的OR为4.0，上消化道GIAD的OR为7.0，p<0.001）、高血压（下消化道GIAD的OR为2.3，上消化道GIAD的OR为2.8，p<0.001）和主动脉瓣狭窄（下消化道GIAD的OR为2.8，上消化道GIAD的OR为2.0，p<0.001）。其他显著的危险因素包括缺血性心脏病、慢性肾衰竭、女性和慢性阻塞性肺疾病。有趣的是，在患有恶性肿瘤的患者中，上消化道和下消化道GIAD的发病率均显著较低。
识别与GIAD相关的临床情况和人口统计学因素，可能会提高我们对这种罕见疾病病因和最佳治疗方式的理解。
