Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
Sci Rep. 2024 Aug 20;14(1):19237. doi: 10.1038/s41598-024-70331-8.
Dietary micronutrients are integral to the development and progression of constipation; however, the specific relationship between dietary copper intake and constipation has not been thoroughly investigated. This study aims to examine the correlation between dietary copper intake and constipation among U.S. adults, thereby offering novel insights and recommendations for the clinical management and prevention of constipation. Bowel health data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010 were analyzed. Subjects' dietary information was collected through questionnaire records. Multivariate logistic regression analysis, subgroup analysis, and curve fitting analysis were used to assess the correlation between dietary copper intake and chronic constipation. After adjusting for all possible confounders, each unit increase in dietary copper intake (converted to natural logarithms) was associated with a 20% reduction in the prevalence of constipation (OR = 0.80; 95% CI 0.65-0.98; P = 0.037). The interaction P-values for all subgroups were greater than 0.05, indicating that the findings were stable and consistent across subgroups. The present study showed a significant negative association between dietary copper intake and chronic constipation in adults. This finding raises clinical and healthcare professionals' awareness of the impact of dietary trace elements on intestinal health and has important implications for the development of personalized meal plans and rational supplementation of trace copper in patients with constipation.
膳食微量营养素是便秘发生和发展的重要因素；然而，膳食铜摄入量与便秘之间的具体关系尚未得到充分研究。本研究旨在探讨美国成年人膳食铜摄入量与便秘之间的相关性，为便秘的临床管理和预防提供新的见解和建议。对 2005 年至 2010 年期间进行的国家健康和营养检查调查（NHANES）中的肠道健康数据进行了分析。通过问卷记录收集了受试者的饮食信息。采用多变量逻辑回归分析、亚组分析和曲线拟合分析来评估膳食铜摄入量与慢性便秘之间的相关性。在调整了所有可能的混杂因素后，膳食铜摄入量每增加一个单位（转换为自然对数），便秘的患病率降低 20%（OR=0.80；95%CI 0.65-0.98；P=0.037）。所有亚组的交互 P 值均大于 0.05，表明这些发现在亚组之间是稳定且一致的。本研究表明，成年人膳食铜摄入量与慢性便秘之间存在显著的负相关关系。这一发现提高了临床和医疗保健专业人员对膳食微量元素对肠道健康影响的认识，对制定个性化膳食计划和合理补充便秘患者的微量铜具有重要意义。
