School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Department of Neurosurgery, New York University Grossman School of Medicine, New York City, NYC, USA.
Neurosurg Rev. 2024 Aug 21;47(1):448. doi: 10.1007/s10143-024-02695-4.
In this review, the author highlights the role of IL4 in mitigating all the "hallmarks" of cancer growth and resistance to current immunotherapy, providing a framework for its role in GBM as well as guideline for future treatment regimens. This review is organized around six strategies by which IL4 contributes to the immune resistance seen in GBM: (i) apoptosis evasion, (ii) self-sufficiency in growth signals, (iii) insensitivity to anti-growth signals, (iv) invasion and metastasis, (v) limitless replicative potential, (vi) sustained angiogenesis.
在这篇综述中，作者强调了 IL4 在减轻癌症生长和对当前免疫疗法的耐药性的所有“特征”中的作用，为其在 GBM 中的作用以及未来治疗方案的指导方针提供了框架。本综述围绕 IL4 有助于 GBM 中免疫抵抗的六种策略进行组织：（i）凋亡逃逸，（ii）生长信号自给自足，（iii）对抗生长信号不敏感，（iv）侵袭和转移，（v）无限复制潜力，（vi）持续血管生成。
