由-杂环卡宾-PdCl-1-甲基咪唑配合物催化的噻吩与芳基氯的双直接C-H键芳基化反应
Double Direct C-H Bond Arylation of Thiophenes with Aryl Chlorides Catalyzed by the -Heterocyclic Carbene-PdCl-1-methylimidazole Complex.
作者信息
Wang Chao, Zhou Quan, Liang Ke-Jiang, Bo Xiao-Xu, Ding Yi-Hong, Shao Li-Xiong
机构信息
College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province 325035, People's Republic of China.
Department of Agriculture and Biotechnology, Wenzhou Vocational College of Science and Technology, No. 1000 Liuhongqiao Road, Wenzhou 325006, People's Republic of China.
出版信息
J Org Chem. 2024 Sep 6;89(17):12533-12539. doi: 10.1021/acs.joc.4c01478. Epub 2024 Aug 21.
With the combination of the -heterocyclic carbene-PdCl-1-methylimidazole complex and CuO, we succeeded in the first example of double direct C-H bond arylation reactions between thiophenes and aryl chlorides, giving the desired 2,5-diarylated thiophenes in moderate to high yields under suitable conditions, consistent with the density functional theory calculations.
通过将-杂环卡宾-PdCl-1-甲基咪唑配合物与CuO相结合，我们成功实现了噻吩与芳基氯之间双直接C-H键芳基化反应的首例，在合适条件下以中等至高收率得到了所需的2,5-二芳基噻吩，这与密度泛函理论计算结果一致。
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