视网膜静脉阻塞患者地塞米松植入术后中心视网膜厚度变异性作为视力预测因素的研究

Central Retinal Thickness Variability as a Predictive Factor for Visual Acuity After Dexamethasone Implant in Retinal Vein Occlusion.

作者信息

Daugirdas Sarunas P, Maatouk Christopher M, Lai Hongxin J, Ogidigben Miller J, Singh Rishi P

出版信息

Ophthalmic Surg Lasers Imaging Retina. 2024 Dec;55(12):722-729. doi: 10.3928/23258160-20240621-04. Epub 2024 Aug 1.

DOI:10.3928/23258160-20240621-04

PMID:39172228

Abstract

BACKGROUND AND OBJECTIVE

Investigate central retinal thickness (CRT) variability and changes in best-corrected visual acuity (BCVA) after 12 months in patients with retinal vein occlusion (RVO) treated with dexamethasone intravitreal implants.

PATIENTS AND METHODS

Post hoc analyses of two randomized trials in patients with macular edema associated with branch or central RVO treated with a 0.7-mg dexamethasone implant. Central retinal thickness standard deviation (CRT-SD) and central retinal thickness amplitude (CRT-A) were measures of variability. Analyses included multinomial and simple linear regression.

RESULTS

In 400 patients, CRT-SD and CRT-A were significantly associated with central RVO, second dexamethasone implant, and baseline CRT. Baseline BCVA was associated with CRT-A. CRT-SD and CRT-A were significantly correlated with a 12-month change in BCVA (effect sizes of -0.032 and -0.013 letters/µm; < 0.001). Patients in the highest CRT-SD quartile gained significantly fewer letters (+1.88 letters; 95% CI: -0.46 to 4.23).

CONCLUSION

Greater CRT variability was associated with smaller BCVA improvements in patients with RVO treated with dexamethasone implants. .

摘要

背景与目的

研究玻璃体内植入地塞米松治疗的视网膜静脉阻塞（RVO）患者12个月后的中央视网膜厚度（CRT）变异性及最佳矫正视力（BCVA）变化。

患者与方法

对两项随机试验进行事后分析，这些试验的患者为伴有黄斑水肿的分支或中央RVO，接受0.7毫克地塞米松植入物治疗。中央视网膜厚度标准差（CRT-SD）和中央视网膜厚度振幅（CRT-A）是变异性的测量指标。分析包括多项和简单线性回归。

结果

在400例患者中，CRT-SD和CRT-A与中央RVO、第二次地塞米松植入以及基线CRT显著相关。基线BCVA与CRT-A相关。CRT-SD和CRT-A与BCVA的12个月变化显著相关（效应大小分别为-0.032和-0.013字母/μm；P<0.001）。CRT-SD最高四分位数的患者视力提高的字母数显著较少（+1.88字母；95%置信区间：-0.46至4.23）。