Unidad de Cuidados Intensivos, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. E-mail:
Unidad de Cuidados Intensivos, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Medicina (B Aires). 2024;84(4):672-681.
Critically ill patients often develop the Post-Intensive Care Syndrome (PICS). Current sedation guidelines mainly rely on intravenous agents. Inhaled sedatives are a promising alternative with favorable pharmacokinetics and potential benefits in critical care settings. However, their application in Latin America remains unexplored.
Case-series study that included adult ICU patients who underwent deep sedation with sevoflurane using the SEDANA anesthetic conserving device. Data on demographics, sedation protocols, adverse events, and outcomes were collected. Statistical analysis assessed changes over time in laboratory parameters.
Eleven patients were included, with sevoflurane administered via artificial airways. Inhaled sedation led to the successful cease of intravenous sedatives in 10 of 11 patients, and reduction of at least 30% in opioid dose. No significant adverse effects were observed. Barriers to adherence included device-related issues and challenges in healthcare staff training.
Sevoflurane effectively achieved sedation goals in ICU patients, reducing the need for additional sedatives and opioids. Our findings support the safety and efficacy of inhaled sedatives in ICU settings and highlight the importance of further research in this area. Longer-term studies are needed to fully determine the impact of inhaled sedatives in ICU patients.
危重症患者常发生 ICU 后综合征（PICS）。目前的镇静指南主要依赖于静脉药物。吸入性镇静剂具有良好的药代动力学特性，在重症监护环境中具有潜在益处，是一种很有前途的替代药物。然而，它们在拉丁美洲的应用仍有待探索。
这是一项包含成年 ICU 患者的病例系列研究，这些患者使用 SEDANA 麻醉保存装置接受七氟醚深度镇静。收集人口统计学、镇静方案、不良事件和结局的数据。统计分析评估了实验室参数随时间的变化。
共纳入 11 例患者，通过人工气道给予吸入性镇静。11 例患者中有 10 例通过吸入性镇静成功停止了静脉镇静药物，阿片类药物的剂量减少了至少 30%。未观察到明显的不良事件。遵医障碍包括设备相关问题和医护人员培训方面的挑战。
七氟醚可有效达到 ICU 患者的镇静目标，减少对其他镇静药物和阿片类药物的需求。我们的研究结果支持在 ICU 环境中使用吸入性镇静剂的安全性和有效性，并强调了在该领域进一步研究的重要性。需要进行更长时间的研究，以充分确定吸入性镇静剂对 ICU 患者的影响。
