Emerg Infect Dis. 2024 Sep;30(9):1872-1883. doi: 10.3201/eid3009.231238.
Cutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp. usually responsible for cutaneous leishmaniasis remain unknown. Other endemic dermotropic Leishmania spp. have not been reported in Sri Lanka. Genome analysis of 27 clinical isolates from Sri Lanka and 32 Old World Leishmania spp. strains found 8 patient isolates clustered with L. tropica and 19 with L. donovani. The L. tropica isolates from Sri Lanka shared markers with strain LtK26 reported decades ago in India, indicating they were not products of recent interspecies hybridization. Because L. tropica was isolated from patients with leishmaniasis in Sri Lanka, our findings indicate L. donovani is not the only cause of cutaneous leishmaniasis in Sri Lanka and potentially explains a haplotype that led to interspecies dermotropic L. donovani hybrids.
皮肤利什曼病在斯里兰卡并不典型，因为导致内脏疾病的利什曼原虫是其病原体。最近描述的利什曼原虫和其他通常导致皮肤利什曼病的利什曼原虫之间杂交种的起源仍然未知。其他地方性亲表皮利什曼原虫在斯里兰卡尚未有报道。对来自斯里兰卡的 27 株临床分离株和 32 株旧世界利什曼原虫株的基因组分析发现，8 株患者分离株与热带利什曼原虫聚类，19 株与利什曼原虫聚类。来自斯里兰卡的热带利什曼原虫分离株与几十年前在印度报道的 LtK26 株有共同标记，表明它们不是最近种间杂交的产物。由于热带利什曼原虫从斯里兰卡的利什曼病患者中分离出来，我们的发现表明利什曼原虫不是斯里兰卡皮肤利什曼病的唯一病因，并可能解释了导致种间亲表皮利什曼原虫杂交的单倍型。
