Xu Zhengyang, Wang Yukun, Chen Xi, Lin Kan, Liu Linbo
School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
Changchun Institute of Optics, Fine Mechanics and Physics, Changchun, China.
Sci Rep. 2024 Aug 22;14(1):19464. doi: 10.1038/s41598-024-68924-4.
Axial velocity gradient (AVG) in the optical coherence tomography angiography (OCTA) signal affects measurement accuracy when the flow is not perpendicular to the scanning beam. We developed a dual beam OCTA method to decouple the contribution of AVG from the decorrelation signal. Decoupling is first verified by phantom experiments which reduces measurement uncertainty from 1.5 to 0.7% (standard deviation). We also tested the method in human skin in vivo and the results indicate that the contribution of AVG to decorrelation signal is reduced.
当血流不垂直于扫描光束时，光学相干断层扫描血管造影（OCTA）信号中的轴向速度梯度（AVG）会影响测量准确性。我们开发了一种双光束OCTA方法，以将AVG的贡献与去相关信号分离。首先通过体模实验验证了这种分离，该实验将测量不确定度从1.5%降低到了0.7%（标准差）。我们还在人体皮肤活体上测试了该方法，结果表明AVG对去相关信号的贡献降低了。
