一个无序区内在 MED13 上适时打开或关闭中介物。
An intrinsically disordered region in MED13 turns Mediator on/off on cue.
机构信息
CNRS EMR 9002 Integrative Structural Biology, Inserm U 1167 - RID-AGE, University of Lille, CHU Lille, Institut Pasteur de Lille, F-59000 Lille, France.
CNRS EMR 9002 Integrative Structural Biology, Inserm U 1167 - RID-AGE, University of Lille, CHU Lille, Institut Pasteur de Lille, F-59000 Lille, France.
出版信息
Mol Cell. 2024 Aug 22;84(16):3005-3007. doi: 10.1016/j.molcel.2024.07.027.
PMID:39178836
Abstract
Complementary studies by Zhao et al. and Chen et al. reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off.
摘要
赵等人和陈等人的补充研究揭示了 MED13 中的一个无规则区域如何控制 RNA 聚合酶 II 和 CDK8 激酶模块与中介体的互斥结合，从而开启和关闭中介体和转录激活。
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