卡瑞霉素治疗1例合并危及生命的肛周混合感染的急性髓系白血病患者：病例报告及文献复习
Carrimycin in a Patient with Acute Myeloid Leukemia Complicated with Life-Threatening Mixed Perianal Infection: A Case Report and Literature Review.
作者信息
Yang Xiawan, Shen Yingying, Hu Tonglin, Li Hangchao, Zhang Yun, Shen Yiping, Wu Dijiong
机构信息
Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, People's Republic of China.
The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
出版信息
Infect Drug Resist. 2024 Aug 21;17:3637-3642. doi: 10.2147/IDR.S475982. eCollection 2024.
BACKGROUND
Perianal infection has a high incidence and mortality rate in patients with acute myeloid leukemia (AML). Sometimes there is a lack of effective anti-infective treatment regimens.
CASE PRESENTATION
A 58-year-old male diagnosed with AML presented with secondary perianal infection and septic shock upon admission. Although multiple pathogen cultivation and antibiotic sensitivity tests indicated the presence of sensitive strains, the corresponding antibiotics were ineffective. As a last resort, carrimycin was introduced, ultimately controlling the infection and leading to disease remission.
CONCLUSION
Carrimycin is a complementary treatment option when conventional antibiotic therapy fails. It operates through multiple mechanisms beyond its antibiotic properties and warrants further investigation.
背景
肛周感染在急性髓系白血病（AML）患者中发病率和死亡率较高。有时缺乏有效的抗感染治疗方案。
病例介绍
一名58岁男性被诊断为AML，入院时出现继发性肛周感染和感染性休克。尽管多次病原体培养和抗生素敏感性试验表明存在敏感菌株，但相应的抗生素治疗无效。作为最后手段，引入了卡里霉素，最终控制了感染并使病情缓解。
结论
当传统抗生素治疗失败时，卡里霉素是一种补充治疗选择。它通过多种机制发挥作用，超出了其抗生素特性，值得进一步研究。
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