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以淋巴结转移为首发表现的尿路上皮癌巢状亚型的临床及病理特征：一例报告

Clinical and Pathological Features of the Nested Subtype of Urothelial Carcinoma With Lymph Node Metastasis as the Initial Presentation: A Case Report.

作者信息

Li Wenhua, Zhang Ying, Lu Baocheng, Yi Min

机构信息

Department of Pathology, Liuzhou Worker's Hospital, Liuzhou, People's Republic of China.

Department of Pathology, Liuzhou People's Hospital, Liuzhou, People's Republic of China.

出版信息

Clin Pathol. 2024 Aug 22;17:2632010X241276943. doi: 10.1177/2632010X241276943. eCollection 2024 Jan-Dec.

DOI:10.1177/2632010X241276943
PMID:39184527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11342308/
Abstract

The nested subtype of urothelial carcinoma (NS-UC), a rare and aggressive bladder cancer, mimics benign bladder lesions but behaves like high-grade urothelial carcinomas. The author reported a rare case of NS-UC, initially presenting with inguinal lymph node metastasis. The tumor cells of NS-UC exhibit minimal cellular atypia, forming small nests, while the tumor cells of lymph node metastatic carcinoma show greater cellular atypia with diverse structures. Immunohistochemistry is helpful in determining the origin of lymph node metastatic carcinoma. NS-UC often presents morphologically similar to benign lesions, which should be given sufficient attention.

摘要

尿路上皮癌的巢状亚型（NS-UC）是一种罕见且侵袭性强的膀胱癌，它虽类似良性膀胱病变，但生物学行为却与高级别尿路上皮癌相似。作者报告了一例罕见的NS-UC病例，最初表现为腹股沟淋巴结转移。NS-UC的肿瘤细胞异型性极小，形成小巢状，而淋巴结转移癌的肿瘤细胞异型性更大，结构多样。免疫组化有助于确定淋巴结转移癌的来源。NS-UC在形态上常与良性病变相似，应予以充分关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/38639c0446d6/10.1177_2632010X241276943-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/16240a127459/10.1177_2632010X241276943-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/0ee632c4f77b/10.1177_2632010X241276943-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/ced6f8299d43/10.1177_2632010X241276943-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/38639c0446d6/10.1177_2632010X241276943-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/16240a127459/10.1177_2632010X241276943-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/0ee632c4f77b/10.1177_2632010X241276943-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/ced6f8299d43/10.1177_2632010X241276943-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a3a/11342308/38639c0446d6/10.1177_2632010X241276943-fig4.jpg

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本文引用的文献

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Nested and Large Nested Subtypes of Urothelial Carcinoma of the Upper Urinary Tract: A Multi-institutional Study.上尿路尿路上皮癌的巢状和大巢状亚型：一项多机构研究。
Mod Pathol. 2023 Dec;36(12):100333. doi: 10.1016/j.modpat.2023.100333. Epub 2023 Sep 15.
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Nested Subtype of Urothelial Carcinoma in the Upper Urinary Tract: A Series of 15 Cases.上尿路尿路上皮癌的嵌套亚型：15例病例系列
Am J Surg Pathol. 2023 Apr 1;47(4):461-468. doi: 10.1097/PAS.0000000000002008. Epub 2022 Dec 19.
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PAX8 positivity in nested variant of urothelial carcinoma: a potential diagnostic pitfall.巢式尿路上皮癌中 PAX8 的阳性表达：一个潜在的诊断陷阱。
Hum Pathol. 2019 Dec;94:11-15. doi: 10.1016/j.humpath.2019.09.012. Epub 2019 Oct 25.
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Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends.膀胱癌发病率和死亡率：全球概述及最新趋势。
Eur Urol. 2017 Jan;71(1):96-108. doi: 10.1016/j.eururo.2016.06.010. Epub 2016 Jun 28.
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Outcomes following radical cystectomy for nested variant of urothelial carcinoma: a matched cohort analysis.巢式尿路上皮癌行根治性膀胱切除术的结局：匹配队列分析。
J Urol. 2013 May;189(5):1670-5. doi: 10.1016/j.juro.2012.11.006. Epub 2012 Nov 6.
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Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma.大巢状变异型尿路上皮癌：23 例酷似 von Brunn 巢和非浸润性乳头状尿路上皮癌倒置生长方式。
Am J Surg Pathol. 2011 Sep;35(9):1337-42. doi: 10.1097/PAS.0b013e318222a653.
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