Moore M A, Satoh K, Kitahara A, Sato K, Ito N
Jpn J Cancer Res. 1985 Jan;76(1):1-4.
Immunohistochemical staining using antirat glutathione S-transferase placental form (GST-P) rabbit antibody demonstrated marked binding to cells of putative preneoplastic lesions induced in both the liver and pancreas of Syrian hamsters by dihydroxy-di-n-propylnitrosamine treatment, whereas background normal-appearing tissue was negative. Thus, a protein showing immunological cross-reaction with rat GST-P is also elevated during pancreatic carcinogenesis and hepatocarcinogenesis in the hamster, suggesting its usefulness as a marker with potential relevance to the mechanisms underlying the neoplastic process.
使用抗大鼠谷胱甘肽S-转移酶胎盘型（GST-P）兔抗体进行的免疫组织化学染色显示，在用二羟基二正丙基亚硝胺处理的叙利亚仓鼠的肝脏和胰腺中诱导的假定癌前病变细胞有明显的结合，而外观正常的背景组织为阴性。因此，在仓鼠胰腺癌发生和肝癌发生过程中，一种与大鼠GST-P有免疫交叉反应的蛋白质也会升高，这表明它作为一种与肿瘤形成过程潜在机制相关的标志物具有实用性。
