Department of Transfusion Medicine, Institute of Hematology and Transfusion Medicine (IHTM), Indiry Gandhi 14, Warsaw 02-776, Poland.
Department of Transfusion Medicine, Institute of Hematology and Transfusion Medicine (IHTM), Indiry Gandhi 14, Warsaw 02-776, Poland.
Transfus Apher Sci. 2024 Oct;63(5):103991. doi: 10.1016/j.transci.2024.103991. Epub 2024 Aug 21.
Sjögren's syndrome (SS) may cause severe dry eye symptoms. One of the therapeutic option known for almost 40 years are autologous serum eye drops (ASEDs). Due to the presence of many pro-inflammatory factors in the autologous serum of SS patients, the use of allogeneic serum is often considered a better option. In our facility almost one-fifth of the patients using allogeneic serum-based eye drops (alloSEDs) suffered from autoimmune diseases, including SS. The study aim was to compare the effectiveness of both ASEDs and alloSEDs in SS patients.
From the group of SS patients using alloSEDs, five female SS patients aged 39-73 years were selected. They had the longest history of the use of the product. The analysis was based on OSDI forms and internal questionnaires which compared the effects of ASEDs and alloSEDs application. The patients used alloSEDs for a period of 5-28 months. All had previously used ASEDs for at least 2 years.
For all five patients the mean OSDI after application of ASEDs and before introducing alloSEDs was 68.71, while the mean OSDI after the use of alloSEDs was 30.49.
In SS the treatment results are better with alloSEDs than with ASEDs. Almost all SS patients who applied both autologous and allogeneic drops reported better effects with the latter as also confirmed by the study cases.
干燥综合征（SS）可引起严重的干眼症状。已知近 40 年来的一种治疗选择是自体血清滴眼剂（ASED）。由于 SS 患者的自体血清中存在许多促炎因子，因此通常认为使用同种异体血清是更好的选择。在我们的机构中，近五分之一使用同种异体血清滴眼剂（alloSEDs）的患者患有自身免疫性疾病，包括 SS。本研究旨在比较 ASED 和 alloSED 在 SS 患者中的疗效。
从使用 alloSED 的 SS 患者中选择了 5 名年龄在 39-73 岁之间的女性 SS 患者。她们使用该产品的历史最长。分析基于 OSDI 表格和内部问卷，比较了 ASED 和 alloSED 应用的效果。患者使用 alloSED 的时间为 5-28 个月。所有患者之前均至少使用 ASED 2 年。
对于所有 5 名患者，使用 ASED 后的平均 OSDI 和使用 alloSED 前的平均 OSDI 为 68.71，而使用 alloSED 后的平均 OSDI 为 30.49。
在 SS 中，alloSED 的治疗效果优于 ASED。几乎所有使用自体和同种异体滴眼液的 SS 患者都报告说，后者的效果更好，研究病例也证实了这一点。
