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粪便微生物群移植影响微生物群，而与肠易激综合征患者的症状缓解无关。

Fecal microbiota transplantation influences microbiota without connection to symptom relief in irritable bowel syndrome patients.

机构信息

Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Faculty of Medicine, University of Helsinki, Helsinki, Finland.

出版信息

NPJ Biofilms Microbiomes. 2024 Aug 28;10(1):73. doi: 10.1038/s41522-024-00549-x.

DOI:10.1038/s41522-024-00549-x
PMID:39191760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11349920/
Abstract

Imbalanced microbiota may contribute to the pathophysiology of irritable bowel syndrome (IBS), thus fecal microbiota transplantation (FMT) has been suggested as a potential treatment. Previous studies on the relationship between clinical improvement and microbiota after FMT have been inconclusive. In this study, we used 16S rRNA gene amplicon and shotgun metagenomics data from a randomized, placebo controlled FMT trial on 49 IBS patients to analyze changes after FMT in microbiota composition and its functional potential, and to identify connections between microbiota and patients' clinical outcome. As a result, we found that the successful modulation of microbiota composition and functional profiles by FMT from a healthy donor was not associated with the resolution of symptoms in IBS patients. Notably, a donor derived strain of Prevotella copri dominated the microbiota in those patients in the FMT group who had a low relative abundance of P. copri pre-FMT. The results highlight the multifactorial nature of IBS and the role of recipient's microbiota in the colonization of donor's strains.

摘要

肠道微生物失衡可能导致肠易激综合征（IBS）的病理生理学改变，因此粪便微生物群移植（FMT）已被提议作为一种潜在的治疗方法。先前关于 FMT 后临床改善与微生物群之间关系的研究尚无定论。在这项研究中，我们使用了来自 49 名 IBS 患者的随机、安慰剂对照 FMT 试验的 16S rRNA 基因扩增子和 shotgun 宏基因组学数据，分析了 FMT 后微生物群落组成及其功能潜力的变化，并确定了微生物群与患者临床结果之间的联系。结果发现，来自健康供体的 FMT 对微生物群落组成和功能谱的成功调节与 IBS 患者症状的缓解无关。值得注意的是，在 FMT 组中，那些 P. copri 丰度较低的患者的肠道微生物群中，Prevotella copri 的一种供体衍生菌株占主导地位。这些结果突出了 IBS 的多因素性质和受体微生物群在供体菌株定植中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/4532c0b1566b/41522_2024_549_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/5d512d07a65a/41522_2024_549_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/5ef2001a849d/41522_2024_549_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/34f7760e2c6e/41522_2024_549_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/a80fe1d8361e/41522_2024_549_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/570ce60704ea/41522_2024_549_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/4532c0b1566b/41522_2024_549_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/5d512d07a65a/41522_2024_549_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/5ef2001a849d/41522_2024_549_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/34f7760e2c6e/41522_2024_549_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/a80fe1d8361e/41522_2024_549_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/570ce60704ea/41522_2024_549_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ac/11349920/4532c0b1566b/41522_2024_549_Fig6_HTML.jpg

相似文献

[1]
Fecal microbiota transplantation influences microbiota without connection to symptom relief in irritable bowel syndrome patients.

NPJ Biofilms Microbiomes. 2024-8-28

[2]
An Open-Labeled Study on Fecal Microbiota Transfer in Irritable Bowel Syndrome Patients Reveals Improvement in Abdominal Pain Associated with the Relative Abundance of Akkermansia Muciniphila.

Digestion. 2018-11-13

[3]
Engraftment of strictly anaerobic oxygen-sensitive bacteria in irritable bowel syndrome patients following fecal microbiota transplantation does not improve symptoms.

Gut Microbes. 2021

[4]
The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study.

Clin Transl Gastroenterol. 2019-4

[5]
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels.

Scand J Gastroenterol. 2019-6

[6]
Relief of irritable bowel syndrome by fecal microbiota transplantation is associated with changes in diversity and composition of the gut microbiota.

J Dig Dis. 2019-7-7

[7]
Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study.

Gut. 2018-7-6

[8]
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study.

Gut. 2019-12-18

[9]
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation.

PLoS One. 2018-11-14

[10]
Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome.

Digestion. 2017

引用本文的文献

[1]
Type 2 Diabetes and the Multifaceted Gut-X Axes.

Nutrients. 2025-8-21

[2]
Effect of fecal microbiota transplantation on gut microbiota functional profile in recipients of allogeneic hematopoietic cell transplantation.

Gut Microbes. 2025-12

[3]
Fecal Microbiota Transplantation for Disorders of Gut-Brain Interaction: Current Insights, Effectiveness, and Future Perspectives.

Curr Gastroenterol Rep. 2025-7-9

本文引用的文献

[1]
Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea.

Aliment Pharmacol Ther. 2023-10

[2]
Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4.

Nat Biotechnol. 2023-11

[3]
Genomic repertoires linked with pathogenic potency of arthritogenic isolated from the gut of patients with rheumatoid arthritis.

Ann Rheum Dis. 2023-5

[4]
Metagenome analysis using the Kraken software suite.

Nat Protoc. 2022-12

[5]
The Effect of Anaerobically Cultivated Human Intestinal Microbiota Compared to Fecal Microbiota Transplantation on Gut Microbiota Profile and Symptoms of Irritable Bowel Syndrome, a Double-Blind Placebo-Controlled Study.

Microorganisms. 2022-9-11

[6]
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases.

Nat Med. 2022-9

[7]
Drivers and determinants of strain dynamics following fecal microbiota transplantation.

Nat Med. 2022-9

[8]
Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome.

Am J Physiol Gastrointest Liver Physiol. 2022-8-1

[9]
Efficacy of Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome at 3 Years After Transplantation.

Gastroenterology. 2022-10

[10]
Multivariable association discovery in population-scale meta-omics studies.

PLoS Comput Biol. 2021-11

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