Lee Jooyoung, Choi Arum, Kim Sukil, Yoo Il Han
Department of Pediatrics, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.
Department of Preventive Medicine and Public Health, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Neurol Int. 2024 Aug 21;16(4):880-890. doi: 10.3390/neurolint16040066.
Population-based data on drug-resistant epilepsy (DRE) are lacking. This retrospective study aimed to determine the prevalence and incidence of pediatric epilepsy and DRE in South Korea using health insurance claims data from the Health Insurance Review and Assessment Service (2013-2022). Epilepsy and DRE prevalence and incidence in children <18 years old were estimated over time and by age and sex. Results showed that the age-standardized prevalence and incidence rates of epilepsy increased. The age-standardized prevalence rate of DRE increased, while the age-standardized incidence rate remained unchanged. The standardized prevalence rate of DRE was 0.26 per 1000 persons, and the average standardized incidence rate of DRE was 0.06 per 1000 persons. The prevalence rate of DRE gradually increased with age, with age 0 demonstrating the highest incidence rate. The prevalence of generalized DRE was the highest across all ages, and incidence was the highest at 0 years. Conversely, the incidence of focal DRE did not change with age. Our study revealed a stable incidence rate of DRE in Korea, despite increased prevalence. DRE incidence was the highest in the first year of life, with the generalized type being the most prevalent.
缺乏基于人群的耐药性癫痫（DRE）数据。这项回顾性研究旨在利用健康保险审查和评估服务机构（2013 - 2022年）的健康保险理赔数据，确定韩国儿童癫痫和DRE的患病率和发病率。对18岁以下儿童的癫痫和DRE患病率及发病率随时间、年龄和性别进行了估计。结果显示，癫痫的年龄标准化患病率和发病率有所上升。DRE的年龄标准化患病率上升，而年龄标准化发病率保持不变。DRE的标准化患病率为每1000人0.26例，DRE的平均标准化发病率为每1000人0.06例。DRE的患病率随年龄逐渐增加，0岁时发病率最高。全身性DRE的患病率在各年龄段中最高，发病率在0岁时最高。相反，局灶性DRE的发病率不随年龄变化。我们的研究表明，尽管患病率有所上升，但韩国DRE的发病率保持稳定。DRE发病率在生命的第一年最高，全身性类型最为普遍。
