Cocuzza Salvatore, Parisi Federica Maria, Spatola Corrado, La Mantia Ignazio, Lechien Jerome Rene, Chiesa-Estomba Carlos, Ferlito Salvatore, Albanese Gianluca, Lentini Mario, Mayo-Yanez Miguel, Fakhry Nicolas, La Rocca Madalina, Maniaci Antonino
Department Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università di Catania, 95125 Catania, Italy.
U.O. Radioterapia Oncologica, A.O.U. Policlinico "G. Rodolico-San Marco" Catania, Via Santa Sofia 78, 95123 Catania, Italy.
J Clin Med. 2024 Aug 15;13(16):4821. doi: 10.3390/jcm13164821.
: Patients treated with definitive radiotherapy for nasopharyngeal carcinoma (NPC) develop severe dysphagia, affecting their quality of life. Traditional prognosis biomarkers are insufficient, leading to a search for new predictors like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). : We retrospectively enrolled 44 NPC patients who underwent definitive radiotherapy between 2010 and 2018. EQUATOR and STROBE network guidelines were adopted. Pre-treatment evaluations were conducted, and post-treatment oropharyngeal dysphagia was assessed using the Sydney Swallow Questionnaire (SSQ) and FEES, then assigning a Dysphagia Outcome and Severity Scale (DOSS) level. Patients were divided based on NLR and PLR cut-offs, comparing subjective dysphagia (SSQ) scores and DOSS results at baseline and after a 5-year follow-up. Multiple linear regression was used for analysis. : At baseline, the mean NLR was 2.52 ± 1.10, and the PLR was 208.40 ± 94.35. Multivariate analysis indicated NLR and PLR as significant predictors of DOSS outcomes ( < 0.001). : Baseline inflammation markers, such as NLR and PLR, may be used to predict dysphagia severity in NPC patients undergoing definitive radiotherapy. These markers could help identify patients at higher risk for severe dysphagia and implement tailored therapeutic and rehabilitative strategies to improve their quality of life. Further studies with larger cohorts are needed to confirm these findings and explore additional prognostic factors for dysphagia outcomes in NPC patients.
接受鼻咽癌（NPC）根治性放疗的患者会出现严重吞咽困难，影响其生活质量。传统的预后生物标志物并不充分，因此人们在寻找新的预测指标，如中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）。我们回顾性纳入了2010年至2018年间接受根治性放疗的44例NPC患者。采用了EQUATOR和STROBE网络指南。进行了治疗前评估，并使用悉尼吞咽问卷（SSQ）和功能性内镜吞咽评估（FEES）对治疗后的口咽吞咽困难进行评估，然后确定吞咽困难结果和严重程度量表（DOSS）水平。根据NLR和PLR的临界值对患者进行分组，比较基线时和5年随访后的主观吞咽困难（SSQ）评分和DOSS结果。采用多元线性回归进行分析。在基线时，平均NLR为2.52±1.10，PLR为208.40±94.35。多变量分析表明NLR和PLR是DOSS结果的重要预测指标（<0.001）。基线炎症标志物，如NLR和PLR，可用于预测接受根治性放疗的NPC患者的吞咽困难严重程度。这些标志物有助于识别严重吞咽困难风险较高的患者，并实施针对性的治疗和康复策略以改善其生活质量。需要进一步开展更大样本量队列的研究来证实这些发现，并探索NPC患者吞咽困难结果的其他预后因素。
