Jagtiani Pemla, Karabacak Mert, Carr Matthew T, Bahadir Zeynep, Morgenstern Peter F, Margetis Konstantinos
School of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA.
Department of Neurosurgery, Mount Sinai Health System, New York, NY 10029, USA.
Children (Basel). 2024 Aug 21;11(8):1025. doi: 10.3390/children11081025.
Retrieve data from the National Cancer Database (NCDB) to examine information on the epidemiological prevalence, treatment strategies, and survival outcomes of pediatric vertebral, sacral and pelvic osteosarcomas.
We reviewed NCDB data from 2008 to 2018, concentrating on vertebral, sacral, and pelvic osteosarcomas in children 0 to 21 years. Our analysis involved logistic and Poisson regression, Kaplan-Meier survival estimates, and Cox proportional hazards models.
The study population included 207 patients. For vertebral osteosarcomas, 62.5% of patients were female, and 78.1% were white. Regional lymph node involvement predicted 80 times higher mortality hazard ( = 0.021). Distant metastasis predicted 25 times higher mortality hazard ( = 0.027). For sacral and pelvic osteosarcomas, 58.3% of patients were male, and 72% were white. Patients with residual tumor were 4 times more likely to have prolonged LOS ( = 0.031). No residual tumor (HR = 0.53, = 0.03) and radiotherapy receipt (HR = 0.46, = 0.034) were associated with lower mortality hazards. Distant metastasis predicted 3 times higher mortality hazard ( < 0.001). Hispanic ethnicity was linked to lower resection odds (OR = 0.342, = 0.043), possibly due to language barriers affecting patient understanding and care decisions.
In conclusion, our examination of NCDB offers a thorough exploration of demographics, treatment patterns, and results, highlighting the importance of personalized approaches to enhance patient outcomes.
从国家癌症数据库（NCDB）检索数据，以研究儿童椎体、骶骨和骨盆骨肉瘤的流行病学患病率、治疗策略及生存结果信息。
我们回顾了2008年至2018年的NCDB数据，重点关注0至21岁儿童的椎体、骶骨和骨盆骨肉瘤。我们的分析包括逻辑回归和泊松回归、Kaplan-Meier生存估计以及Cox比例风险模型。
研究人群包括207名患者。对于椎体骨肉瘤，62.5%的患者为女性，78.1%为白人。区域淋巴结受累预测死亡风险高80倍（P = 0.021）。远处转移预测死亡风险高25倍（P = 0.027）。对于骶骨和骨盆骨肉瘤，58.3%的患者为男性，72%为白人。有残留肿瘤的患者住院时间延长的可能性高4倍（P = 0.031）。无残留肿瘤（HR = 0.53，P = 0.03）和接受放疗（HR = 0.46，P = （此处原文有误，推测应为P = 0.034））与较低的死亡风险相关。远处转移预测死亡风险高3倍（P < 0.001）。西班牙裔与较低的切除几率相关（OR = 0.342，P = 0.043），这可能是由于语言障碍影响患者的理解和护理决策。
总之，我们对NCDB的研究全面探讨了人口统计学、治疗模式和结果，强调了个性化方法对改善患者结局的重要性。
