Węgrzyn Konstancja, Jasińska Agnieszka, Janeczek Kamil, Feleszko Wojciech
Central Clinical Hospital, Medical University of Warsaw, 02-097 Warsaw, Poland.
Department of Pediatric Pneumonology and Allergy, University Clinical Centre, Medical University of Warsaw, 02-097 Warsaw, Poland.
Microorganisms. 2024 Aug 11;12(8):1642. doi: 10.3390/microorganisms12081642.
In recent years, there has been abundant research concerning human microbiome and its impact on the host's health. Studies have shown that not only the commensal bacteria itself, but also postbiotics, understood as inanimate microorganisms, possibly with the presence of their components, may themselves have an effect on various elements of human physiology. In this review, we take a closer look at the specific ways in which postbiotics can alter immune response in allergic asthma, which is one of the most prevalent allergic diseases in today's world and a serious subject of concern. Through altering patients' immune response, not only to allergens but also to pathogens, postbiotics could have a significant role in lowering the number of asthma exacerbations. We suggest that more profound research should be undertaken in order to launch postbiotics into clinical standards of asthma treatment, given the greatly promising findings in terms of their immunomodulating potential.
近年来，关于人类微生物组及其对宿主健康的影响已有大量研究。研究表明，不仅共生细菌本身，而且后生元（被理解为无生命的微生物，可能连同其成分的存在）自身可能对人体生理学的各个方面产生影响。在本综述中，我们更深入地探讨后生元改变过敏性哮喘免疫反应的具体方式，过敏性哮喘是当今世界最普遍的过敏性疾病之一，也是一个严重的关注课题。通过改变患者对过敏原以及病原体的免疫反应，后生元在减少哮喘发作次数方面可能发挥重要作用。鉴于后生元在免疫调节潜力方面的极具前景的发现，我们建议应进行更深入的研究，以便将后生元纳入哮喘治疗的临床标准。
