Pagac Martin Patrick, Gempeler Mathias, Campiche Remo
DSM-Firmenich, Perfumery & Beauty, Wurmisweg 576, CH-4303 Kaiseraugst, Switzerland.
Microorganisms. 2024 Aug 19;12(8):1711. doi: 10.3390/microorganisms12081711.
Effects of pre- and probiotics on intestinal health are well researched and microbiome-targeting solutions are commercially available. Even though a trend to appreciate the presence of certain microbes on the skin is seeing an increase in momentum, our understanding is limited as to whether the utilization of skin-resident microbes for beneficial effects holds the same potential as the targeted manipulation of the gut microflora. Here, we present a selection of molecular mechanisms of cross-communication between human skin and the skin microbial community and the impact of these interactions on the host's cutaneous health with implications for the development of skin cosmetic and therapeutic solutions. yeasts, as the main fungal representatives of the skin microfloral community, interact with the human host skin via lipid mediators, of which several are characterized by exhibiting potent anti-inflammatory activities. This review therefore puts a spotlight on and provides a comprehensive overview of the current state of knowledge about these fungal-derived lipid mediators and their capability to reduce aesthetical and sensory burdens, such as redness and itching, commonly associated with inflammatory skin conditions. Finally, several examples of current skin microbiome-based interventions for cosmetic solutions are discussed, and models are presented for the use of skin-resident microbes as endogenous bio-manufacturing platforms for the in situ supplementation of the skin with beneficial metabolites.
益生元和益生菌对肠道健康的影响已得到充分研究，针对微生物群的解决方案也已商业化。尽管人们越来越倾向于认识到皮肤表面某些微生物的存在，但对于利用皮肤常驻微生物产生有益效果是否具有与靶向操纵肠道微生物群相同的潜力，我们的了解仍然有限。在此，我们介绍了人类皮肤与皮肤微生物群落之间相互交流的一些分子机制，以及这些相互作用对宿主皮肤健康的影响，并探讨了其对皮肤美容和治疗方案开发的意义。酵母作为皮肤微生物群落的主要真菌代表，通过脂质介质与人类宿主皮肤相互作用，其中几种脂质介质具有强大的抗炎活性。因此，本综述重点关注并全面概述了目前关于这些真菌衍生脂质介质的知识现状，以及它们减轻通常与炎症性皮肤病相关的美学和感官负担（如发红和瘙痒）的能力。最后，讨论了当前基于皮肤微生物群的美容解决方案干预措施的几个例子，并提出了将皮肤常驻微生物用作内源性生物制造平台，用于在皮肤原位补充有益代谢物的模型。
