Austrian Research Group for Regenerative and Orthopedic Medicine (AURROM), 1050 Vienna, Austria.
Austrian Society of Regenerative Medicine (RegMed), 1010 Vienna, Austria.
Nutrients. 2024 Aug 14;16(16):2695. doi: 10.3390/nu16162695.
Various nutritional supplements are available over the counter, yet few have been investigated in randomized controlled trials. The rationale for using the specific mix of nutritional substances including collagen type II, hyaluronic acid, n-acetyl-glucosamine, bamboo extract, L-lysine, and vitamin C is the assumption that combining naturally occurring ingredients of the intervertebral disc would maintain spine function. This double-blinded, placebo-controlled randomized trial aimed to evaluate the efficacy of a nutraceutical supplement mix in the management of lumbar osteochondrosis. Fifty patients were randomly assigned to either the supplement or placebo group in a 1:1 ratio. Patient-Reported Outcome Measures (PROMs) included the Oswestry Disability Index (ODI), the visual analogue scale for pain (pVAS), short form-12 (SF-12) physical and mental component summary subscale scores (PCS and MCS, respectively), and global physical activity questionnaire (GPAQ). Magnetic resonance imaging (MRI) was used to evaluate degenerative changes of intervertebral discs (IVD) including Pfirrmann grades as well as three-dimensional (3D) volume measurements. Data were collected at baseline and after the 3-month intervention. None of the PROMs were significantly different between the supplement and placebo groups. Disc degeneration according to Pfirrmann classifications remained stable during the 3-month intervention in both groups. Despite no significance regarding the distribution of Pfirrmann grade changes (improvement, no change, worsening; = 0.259), in the supplement group, one patient achieved a three-grade improvement, and worsening of Pfirrmann grades were only detected in the placebo group (9.1%). Furthermore, in-depth evaluations of MRIs showed significantly higher 3D-measured volume changes (increase) in the supplement (+740.3 ± 796.1 mm) compared to lower 3D-measured volume changes (decrease) in the placebo group (-417.2 ± 875.0 mm; < 0.001). In conclusion, this multi-nutrient supplement might not only stabilize the progression of lumbar osteochondrosis, but it might also potentially even increase IVD volumes as detected on MRIs.
各种营养补充剂都可以在柜台买到,但很少有经过随机对照试验的研究。使用包括 II 型胶原蛋白、透明质酸、N-乙酰葡萄糖胺、竹提取物、L-赖氨酸和维生素 C 在内的特定混合营养物质的基本原理是,假设组合椎间盘的天然成分将维持脊柱功能。这项双盲、安慰剂对照的随机试验旨在评估一种营养补充剂混合物在腰椎骨关节炎治疗中的疗效。50 名患者以 1:1 的比例随机分配到补充剂或安慰剂组。患者报告的结果测量(PROMs)包括 Oswestry 残疾指数(ODI)、疼痛视觉模拟量表(pVAS)、简短形式 12(SF-12)身体和心理成分综合量表评分(PCS 和 MCS,分别)和全球体力活动问卷(GPAQ)。磁共振成像(MRI)用于评估椎间盘(IVD)的退行性变化,包括 Pfirrmann 分级以及三维(3D)体积测量。数据在基线和 3 个月干预后收集。补充剂和安慰剂组之间的 PROMs 均无显著差异。在 3 个月的干预过程中,两组的 Pfirrmann 分类椎间盘退变均保持稳定。尽管 Pfirrmann 分级变化(改善、无变化、恶化;=0.259)的分布无显著性差异,但在补充剂组中,有 1 例患者获得了 3 级改善,而仅在安慰剂组中发现了 Pfirrmann 分级恶化(9.1%)。此外,对 MRI 的深入评估显示,补充剂组的 3D 测量体积变化(增加)明显高于安慰剂组(+740.3±796.1mm),而安慰剂组的 3D 测量体积变化(减少)较低(-417.2±875.0mm;<0.001)。总之,这种多营养补充剂不仅可能稳定腰椎骨关节炎的进展,而且还可能潜在地增加 MRI 上检测到的椎间盘体积。