Wattanawiggan Ratchapoom, Chansakaow Sunee, Jantrawut Pensak, Panraksa Pattaraporn, Jiaranaikulwanitch Jutamas, Udomsom Suruk, Worajittiphon Patnarin, Tipduangta Pratchaya
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Biomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.
Plants (Basel). 2024 Aug 18;13(16):2294. doi: 10.3390/plants13162294.
Erectile dysfunction (ED) refers to the inability of the penis to maintain a firm erection during sexual activity. Mucuna, or , contains levodopa, a compound showing promise in ED treatment. However, formulating Mucuna extract into tablet dosage forms is challenging due to its semisolid nature. This study aimed to develop sustained-release tablets containing Mucuna extract via semisolid extrusion 3D printing. Eudragit RS PO (Eudragit) served as a sustained-release polymer, with poly (vinyl alcohol) (PVA) as a co-polymer for forming the tablet matrices. This study had the following two main phases: screening, which identified the factors affecting the printability, and optimization, which focused on the factors influencing the levodopa release and its consistency. The results showed that both the polymeric solid percentage content (PSPC) in the semisolid slurry and the Eudragit-PVA ratio significantly affected the printability. All of the formulations were printable, and the PSPC and Eudragit-PVA ratios were incorporated into the optimized model. The desired formulation, achieving targeted levodopa release and consistency, had a PSPC of 58.8% and a Eudragit-PVA ratio of 2.87:1. In conclusion, semisolid extrusion 3D printing guided by the design of experiments (DoE) proved feasible for producing reliable 3D-printed tablets with consistent active ingredients and desired release rates.
勃起功能障碍（ED）是指阴茎在性活动期间无法维持坚挺勃起。刺蒺藜，即 ，含有左旋多巴，这是一种在ED治疗中显示出前景的化合物。然而，由于刺蒺藜提取物的半固体性质，将其制成片剂剂型具有挑战性。本研究旨在通过半固体挤出3D打印开发含刺蒺藜提取物的缓释片。Eudragit RS PO（尤特奇）用作缓释聚合物，聚乙烯醇（PVA）作为共聚物用于形成片剂基质。本研究有以下两个主要阶段：筛选，确定影响可打印性的因素；优化，关注影响左旋多巴释放及其一致性的因素。结果表明，半固体浆料中的聚合物固体百分比含量（PSPC）和尤特奇 - PVA比例均显著影响可打印性。所有配方均可打印，且PSPC和尤特奇 - PVA比例被纳入优化模型。达到目标左旋多巴释放和一致性的理想配方，其PSPC为58.8%，尤特奇 - PVA比例为2.87:1。总之，以实验设计（DoE）为指导的半固体挤出3D打印被证明对于生产具有一致活性成分和期望释放速率的可靠3D打印片剂是可行的。
